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Journal
2009 | 7 | 1 | 8-13
Article title

Re-evaluated data of dissociation constants of alendronic, pamidronic and olpadronic acids

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Abstracts
EN
The dissociation constants of (4-amino-1-hydroxybutylidene)bisphosphonic (alendronic) acid, (3-(dimethylamino)-1-hydroxypropylidene)bisphosphonic (olpadronic) acid and (3-amino-1-hydroxypropylidene)bisphosphonic (pamidronic) acid were obtained in aqueous solutions (0.10 M KCl) and micellar solutions of cetylpyridinium chloride (0.10 M CPC) at 25.0°C. With the exception of the third dissociation constant of alendronic acid, the dissociation constants of alendronic, olpadronic and pamidronic acids in aqueous solutions matched literature data. The possibility of sodium alendronate determination by acid-base titration by NaOH solution was theoretically grounded on the basis of re-evaluated data of alendronic acid dissociation constants. [...]
Publisher

Journal
Year
Volume
7
Issue
1
Pages
8-13
Physical description
Dates
published
1 - 3 - 2009
online
23 - 12 - 2008
Contributors
  • Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine
author
  • Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine
author
  • Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine
author
  • A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russian Federation
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-008-0099-z
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