Re-evaluated data of dissociation constants of alendronic, pamidronic and olpadronic acids

• Authors: Alexander Boichenko , Vadim Markov , Hoan Kong , Anna Matveeva , Lidia Loginova
• Languages of publication: EN

Abstracts

EN

The dissociation constants of (4-amino-1-hydroxybutylidene)bisphosphonic (alendronic) acid, (3-(dimethylamino)-1-hydroxypropylidene)bisphosphonic (olpadronic) acid and (3-amino-1-hydroxypropylidene)bisphosphonic (pamidronic) acid were obtained in aqueous solutions (0.10 M KCl) and micellar solutions of cetylpyridinium chloride (0.10 M CPC) at 25.0°C. With the exception of the third dissociation constant of alendronic acid, the dissociation constants of alendronic, olpadronic and pamidronic acids in aqueous solutions matched literature data. The possibility of sodium alendronate determination by acid-base titration by NaOH solution was theoretically grounded on the basis of re-evaluated data of alendronic acid dissociation constants. [...]

Keywords

EN

Alendronate; Olpadronate, pamidronate; dissociation constant; Micellar media effect

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2009
• Volume: 7
• Issue: 1
• Pages: 8-13

Dates

published

1 - 3 - 2009

online

23 - 12 - 2008

Contributors

author

Alexander Boichenko

• Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine

author

Vadim Markov

• Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine

author

Hoan Kong

• Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine

author

Anna Matveeva

• A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russian Federation

author

Lidia Loginova

• Department of Chemical Metrology, Kharkov V.N. Karazin National University, 61077, Kharkov, Ukraine

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Identifiers

DOI

10.2478/s11532-008-0099-z