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2008 | 6 | 2 | 154-160
Article title

Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

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EN
Abstracts
EN
Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions. [...]
Keywords
Publisher
Journal
Year
Volume
6
Issue
2
Pages
154-160
Physical description
Dates
published
1 - 6 - 2008
online
17 - 4 - 2008
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-008-0008-5
Identifiers
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