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Number of results

Journal

2008 | 6 | 2 | 154-160

Article title

Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

Content

Title variants

Languages of publication

EN

Abstracts

EN
Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions. [...]

Keywords

Publisher

Journal

Year

Volume

6

Issue

2

Pages

154-160

Physical description

Dates

published
1 - 6 - 2008
online
17 - 4 - 2008

Contributors

author
  • Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt
  • Department of Chemistry, Faculty of Science, University of Tanta, 31527, Tanta, Egypt
author
  • Department of Chemistry, University of Bremen, P.O. Box 330440, D-28334, Bremen, Germany

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-008-0008-5
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