Preferences help
enabled [disable] Abstract
Number of results
2015 | 86 | 4 | 172-176
Article title

Biological Properties Of Benzopyran-Based Platinum (Ii) Complexes

Title variants
Languages of publication
The aim of the study was to analyze the physicochemical synthesized complex 3 [(1,3- thiazol -2- ylimino) methyl)]-4H- chromene -4 -one with tetrachloroplatinate(II) dipotassium and determination peroxidase activity and glutathione (GPX) in red blood cells of cancer patients and healthy subjects. Materials and methods. Tests were carried out with the approval of the Bioethics Committee No. RNN/260/08/KB. Blood was collected into tubes with anticoagulant (heparin lithium). Determination of glutathione peroxidase activity was performed by methods of Little and O’Brien in 20 person groups hospitalized at the Department of General and Colorectal Surgery Veterans General Hospital in Łódź. Results. The study was an increase of activity in the control without the compound and after the introduction of the complex relative to the treatment groups. In healthy subjects, without the use of glutathione peroxidase complex averaged 73.25 ± 23.88 U / g Hb after application of the compound corresponds to the reference group 81.01 ± 25.94 U / g Hb. In contrast, in patients without the use of the complex activity amounted to 42.85 ± 27.49 U / g Hb. In the study group, which uses synthesized complex GPX activity corresponds to 67.72 ± 13.44 U / g Hb. Conclusions. The obtained results underline that the introduction of significant blood antioxidant complex research has a significant impact on the results of the determinations. Statistically significant (p < 0.05) difference occurred in both test and no relation to the administration of the complex in relation to the control of 1. 2.
Physical description
1 - 4 - 2014
16 - 3 - 2014
27 - 6 - 2014
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
  • Social Academy of Sciences in Łódź
  • Department of Chest Surgery, General and Oncological Surgery University Hospital WAM and CSW Medical University in Łódź
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
  • 1. Balch J: Super antyoksydanty. Leki XXI wieku w naszym jedzeniu. Amber, Warszawa 2000; 10-60.
  • 2. Antolovich M, Prenzler PD, Patsalides E et al.: Methods for testing antioxidant activity. Analyst 2002; 127: 183-98.
  • 3. Conner E, Grisham M,G: Inflammation, free radicals and antioxidants. Nutrition 1996; 12: 274-77.[Crossref][WoS][PubMed]
  • 4. Czarnecki R, Szaflarska-Czerwionka M, Kędziora J et al.: Assessment of concentration of oxidative stress parameters in children and teenagers with inflammatory bowel diseases. Przegl Gastroenterol 2009; 4: 188-92.
  • 5. Little C et al.: Intracellular GSH-peroxidase with a lipid peroxide substrate. Biophys Res Commun 1968; 31: 145-50.
  • 6. Kupcewicz B, Sobiesiak K, Malinowska K et al.: Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme. Med Chem Res 2013; 22(5): 2395-02.[Crossref]
  • 7. Lin TL, Beal MF et al.: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787-95.
  • 8. Choi J, Rees HD, Weintraub ST et al.: Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J BiolChem 2005; 280: 11648-55.
  • 9. Kubiak K, Malinowska K, Langner E et al.: Wpływ związków koordynacyjnych Cu(II) na aktywność enzymów antyoksydacyjnych Katalazy i Dysmutazy ponadtlenkowej u chorych na raka jelita grubego. Pol Przegl Chir 2011; 83: 282-92.
  • 10. Klimczak A: Badanie aktywności wybranych enzymów antyoksydacyjnych u chorych na raka jelita grubego. PML 2009; 162: 470-74.
  • 11. Malinowska K, Modranka R, Kubiak K i wsp: Badanie aktywności przeciwnowotworowej nowych związków koordynacyjnych platyny (II) i palladu (II). PML 2009; 151: 57-62.
  • 12. Malinowska K, Modranka R., Kubiak K i wsp.: Aktywność biologiczna - in vitro nowych związków koordynacyjnych Pt(II) I Pd(II).PML 2009; 151: 52-57.
  • 13. Kładna A, Berczyński P, Piechowska T et al.: Studies on the antioxidant activities of some new chromone compounds. Luminescence. 2014; 10: 1002-2631.
  • 14. Ciesielska E, Szuławska A, Studzian K et al.: Comparative studies on the mechanism of cytotoxic action of novel platinum II complexes with pyrazole ligands. J Inorg Biochem 2006; 100: 1579-85.
  • 15. Van Kampen EJ, Zijlstra WG. Standardization of hemoglobinometry II. The hemiglobincyanide method. Clin Chim Acta 1961; 6: 538-44.[Crossref]
  • 16. Kubiak K, Klimczak A, Dziki Ł: Synthesis and pro-antioxidant properties of Cu(II) complexes with pyrazole ligands. Pol Merk Lek 2010; 163: 22-25.
  • 17. Kostyuk VA, Patapovich A I , Strigunova EN et al.: Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase. Arch Biochemy and Biophysics 2004; 428: 204-08.
  • 18. El Amrani FBA, Perello L, Real JA et al.: Oxidative DNA cleavage induced by an iron(III) flavonoid complex: Syntehesis, crystal structure and characterization of chlorobis(flavonolato) (methanol) iron (III) complex. Inorg Biochim 2006; 100: 1208-18.
  • 19. Malinowska K, Modranka R: Wpływ związków chromonu na aktywność wybranych enzymów antyoksydacyjnych u chorych ograniczonych ruchowo. PML 2010; 163: 26-28.
  • 20. Kostka K, Modranka R: The Synthesis of Chromone-3-Methanephosphonic Acid and Chromone -2-Methanephosphonic Acid. Phosphorus, Sulfur and Silicon 1991; 57: 279.
  • 21. Nawrot-Modranka J, Nawrot E, Graczyk J: In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone. Europ J Med Chem 2006; 41: 1301.
  • 22. Budzisz E, Małecka M. Lorenz IP et al.: Synthesis, cytotoxic effect and structure - reactivity relationship of Pd(II) complexes with coumarin derivatives. Inorg Chem 2006; 45(24): 9688.[Crossref]
  • 23. Zhao ZS, Khan S, P. O΄Brien J: Catecholic Iron Complexes as Cytoprotetive Superoxide Scavengers against Hypoxia: Reoxygenation Injury in Isolated Hepatocytes. Biochem Pharmacology 1998; 56: 825.
  • 24. Budzisz E, Miernicka M, Lorenz IP et al.: Synthesis, X-ray structures and cytotoxic activity of platinum(II), palladium(II) and copper(II) complexes with chelating ligands. Eur J Med Chem 2010; 45(6): 2613-21.[Crossref][PubMed]
  • 25. Małecka M, Ciołkowski M, Budzis E: 2-Methoxy-3-[(3,4,5-trimethoxy-anilino)methyl-idene)-3- ,4-dihydro-2H-1-benzopyran-4-one. Acta Crystallogr 2009; 66: 246.
  • 26. Budzisz E, Krajewska U, Róźalski M: Cytotoxic and proapoptotic effects of new Pd(II) and Pt(II)-complexes with 3-ethanimidoyl-2-methoxy-2H-1,2-benzoxaphosphinin-4-ol-2-oxide. Pol J Pharmacol 2004; 56(4): 473-78.[PubMed]
  • 27. Małecka M, Massa W, Budzisz E: +/-(4-Oxo-4- chromen-2-yl)metyl acetale. Acta Crysttalogr E2004; 60: 762-64.
  • 28. Zyner E, Graczyk J, Ochocki J: Pt(II) and Pd(II) complexes of 3- aminoflavone. In vitro in vivo evaluation. Pharmazie 1999; 54 (12): 945-46. [PubMed]
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.