Biological Properties Of Benzopyran-Based Platinum (Ii) Complexes

• Authors: Katarzyna Malinowska , Roman Modranka , Ireneusz Majsterek , Piotr Misiak
• Languages of publication: EN

Abstracts

EN

The aim of the study was to analyze the physicochemical synthesized complex 3 [(1,3- thiazol -2- ylimino) methyl)]-4H- chromene -4 -one with tetrachloroplatinate(II) dipotassium and determination peroxidase activity and glutathione (GPX) in red blood cells of cancer patients and healthy subjects. Materials and methods. Tests were carried out with the approval of the Bioethics Committee No. RNN/260/08/KB. Blood was collected into tubes with anticoagulant (heparin lithium). Determination of glutathione peroxidase activity was performed by methods of Little and O’Brien in 20 person groups hospitalized at the Department of General and Colorectal Surgery Veterans General Hospital in Łódź. Results. The study was an increase of activity in the control without the compound and after the introduction of the complex relative to the treatment groups. In healthy subjects, without the use of glutathione peroxidase complex averaged 73.25 ± 23.88 U / g Hb after application of the compound corresponds to the reference group 81.01 ± 25.94 U / g Hb. In contrast, in patients without the use of the complex activity amounted to 42.85 ± 27.49 U / g Hb. In the study group, which uses synthesized complex GPX activity corresponds to 67.72 ± 13.44 U / g Hb. Conclusions. The obtained results underline that the introduction of significant blood antioxidant complex research has a significant impact on the results of the determinations. Statistically significant (p < 0.05) difference occurred in both test and no relation to the administration of the complex in relation to the control of 1. 2.

Keywords

EN

flavones; Pt(II) complexes

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2015
• Volume: 86
• Issue: 4
• Pages: 172-176

Dates

published

1 - 4 - 2014

received

16 - 3 - 2014

online

27 - 6 - 2014

Contributors

author

Katarzyna Malinowska

• Department of Clinical Chemistry and Biochemistry, Medical University in Łódź

author

Roman Modranka

• Social Academy of Sciences in Łódź

author

Ireneusz Majsterek

• Department of Chest Surgery, General and Oncological Surgery University Hospital WAM and CSW Medical University in Łódź

author

Piotr Misiak

• Department of Clinical Chemistry and Biochemistry, Medical University in Łódź

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Identifiers

DOI

10.2478/pjs-2014-0031