The role of Th17 lymphocytes in pathogenesis of autoimmune arthritides

• Authors: Katarzyna Pogoda , Maria Pyszniak , Magdalena Bańka , Beata Rybojad , Jacek Tabarkiewicz
• Languages of publication: EN

Abstracts

EN

Th17 cells are newly described population of lymphoctyes, that recruits neutrophils to the site of inflammation and activate inflammatory phenotype of various tissues. They also play a pivotal role in autoimmune diseases and cancers. These cells secrete mainly different isoforms of IL-17, but also IL-21 and IL-22. Rheumatoid arthritis and juvenile idiopathic arthritis are the most common autoimmune joints’ inflammatory disease, affecting respectively adults and children. For a long time the immunopathogenesis of autoimmune diseases has been associated with Th1 lymphocytes. This hypothesis has changed after the discovery of Th17 cells, which are thought to be key mediators of autoimmune arthritides

Keywords

EN

rheumatoid arthritis; juvenile idiopathic arthritis; Th17 lymphocytes

• Publisher: De Gruyter Open
• Journal: Polish Journal of Public Health
• Year: 2015
• Volume: 124
• Issue: 1
• Pages: 55-58

Dates

published

1 - 3 - 2014

online

23 - 4 - 2014

Contributors

author

Katarzyna Pogoda

• Department of Clinical Immunology, Medical University of Lublin, Poland 4A Chodźki Str., 20-059 Lublin tel: [phone]

author

Maria Pyszniak

• Department of Clinical Immunology, Medical University of Lublin, Poland

author

Magdalena Bańka

• Department of Experimental Hematooncology, Medical University of Lublin, Poland

author

Beata Rybojad

• Department of Expert Medical Assistance with Emergency Medicine Unit, Medical University of Lublin, Poland
• Department of Anaesthesiology and Intensive Care, Children’s University Hospital of Lublin, Poland

author

Jacek Tabarkiewicz

• Department of Clinical Immunology, Medical University of Lublin, Poland

References

• 1. Hollenbach JA, Thompson SD, Bugawan TL, et al. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthrit Rheumat. 2010;62:1781-91.[Crossref]
• 2. Reiner SL. Development in motion: Helper T cells at work. cell. 2007;129(1):33-6.
• 3. Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008;223:87-113.
• 4. Ouyang W, Filvaroff E, Hu Y, Grogan J. Novel therapeutic targets along the Th17 pathway. Eur J Immunol. 2009;39(3):634-75.
• 5. Pappu R, Ramirez-Carrozzi V, Sambandam A. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunol. 2011;134:8-16.
• 6. Reynolds JM, Angkasekwinai P, Dong C. IL-17 family member cytokines: regulation, and function in innate immunity. Cytokine Growth Factor Rev. 2010;21(6):413-23.[Crossref][WoS]
• 7. Kolls JK, Khader SA. The role of Th17 cytokines in primary mucosal immunity. Cytokine Growth Factor Rev. 2010;21(6):443-8.[Crossref][WoS]
• 8. Pelletier M, Girard D. Biological functions of interleukin-21 and its role in inflammation. The Scientific World J. 2007;7:1715-35.
• 9. Pan HF, Li XP, Zheng SG, Ye DQ. Emerging role of interleukin-22 in autoimmune diseases. Cytokine & Growth Factor Rev. 2013;24:51-7.[WoS]
• 10. Sawney S. Juvenile idiopathic arthritis: Classification, clinical features, and management. Indian J Rheumatol. 2012;7:11-21.[Crossref]
• 11. Postępski J, Tuszkiewicz-Misztal E. Atlas reumatologii dziecięcej. Kraków: Medycyna Praktyczna; 2008. p.29-54.
• 12. Modi S, Soejima M, Levesque MC. The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses. Clin Exp Immunol. 2013;173(1):8-17.
• 13. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheumatol. 1987;30:1205-13.
• 14. Gutcher I, Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation. J Clin Invest. 2007;117:1119-27.[WoS]
• 15. Zhu S, Qian Y. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci. 2012;122:487-511.[WoS]
• 16. Chabaud M, Durand JM, Buchs N, et al. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 1999;42:963-70.
• 17. Nistala K, Adams S, Cambrook H, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci. 2010;107:14751-6.
• 18. Roşu A, Mărgăritescu C, Stepan A, et al. IL-17 patterns in synovium, serum and synovial fluid from treatment-naïve, early rheumatoid arthritis patients. Rom J Morphol Embryol. 2012;53:73-80.
• 19. Liu Y, Ho RC, Mak A. The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis. Int J Rheum Dis. 2012;15:183-7.[Crossref]
• 20. Arroyo-Villa I, Bautista-Caro MB, Balsa A, et al. Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti-CCP seropositivity. PLoS One. 2012;7:e42189.
• 21. van Hamburg JP, Asmawidjaja PS, Davelaar N, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheumatol. 2011;63:73-83.
• 22. Moon YM, Yoon BY, Her YM, et al. IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis. Arthritis Res Ther. 2012;14:R246. [Epub ahead of print].[Crossref][WoS]
• 23. Ito H, Yamada H, Shibata TN, et al. Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R14.[Crossref]
• 24. Pickens SR, Volin MV, Mandelin AM, et al. IL-17 contributes to angiogenesis in rheumatoid arthritis. J Immunol. 2010;184:3233-41.
• 25. Nistala K, Moncrieffe H, Newton KR, et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis & Rheumatism. 2008;58:875-87.[WoS]
• 26. Agarwal S, Misra R, Aggarwal A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol. 2008;35(3):515-9.
• 27. Ziroual S, Ecochard R, Tournadre A, et al. Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J Immunol. 2009;182:3112-20.

Identifiers

DOI

10.2478/pjph-2014-0012