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2015 | 124 | 1 | 55-58

Article title

The role of Th17 lymphocytes in pathogenesis of autoimmune arthritides

Content

Title variants

Languages of publication

EN

Abstracts

EN
Th17 cells are newly described population of lymphoctyes, that recruits neutrophils to the site of inflammation and activate inflammatory phenotype of various tissues. They also play a pivotal role in autoimmune diseases and cancers. These cells secrete mainly different isoforms of IL-17, but also IL-21 and IL-22. Rheumatoid arthritis and juvenile idiopathic arthritis are the most common autoimmune joints’ inflammatory disease, affecting respectively adults and children. For a long time the immunopathogenesis of autoimmune diseases has been associated with Th1 lymphocytes. This hypothesis has changed after the discovery of Th17 cells, which are thought to be key mediators of autoimmune arthritides

Publisher

Year

Volume

124

Issue

1

Pages

55-58

Physical description

Dates

published
1 - 3 - 2014
online
23 - 4 - 2014

Contributors

  • Department of Clinical Immunology, Medical University of Lublin, Poland 4A Chodźki Str., 20-059 Lublin tel: +48 81 756-48-40
  • Department of Clinical Immunology, Medical University of Lublin, Poland
  • Department of Experimental Hematooncology, Medical University of Lublin, Poland
author
  • Department of Expert Medical Assistance with Emergency Medicine Unit, Medical University of Lublin, Poland
  • Department of Anaesthesiology and Intensive Care, Children’s University Hospital of Lublin, Poland
  • Department of Clinical Immunology, Medical University of Lublin, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_pjph-2014-0012
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