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2014 | 1 | 1 |

Article title

Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures


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Ensuring drug loading efficiency and consistency is one of
the most critical stages in engineering drug delivery vectors
based on porous materials. Here we propose a technique
to significantly enhance the effciency of loading by
employing simple and widely available methods: applying
low pressure with and without centrifugation. Our results
point toward the advantages of the proposed method
over the passive loading, especially when the difference
between the dimensions of loaded materials and the pore
diameter is small, an increase of up to 20-fold can be observed.
The technique described in this study can be used
for efficient and reproducible loading of porous materials
with therapeutic molecules, nanoparticles and contrast
imaging agents for biomedical applications.








Physical description


29 - 5 - 2014


  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
  • Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
  • Houston Methodist Research Institute, Department of Nanomedicine, 6670 Bertner Ave, R7-122, Houston, TX 77030. Tel: 713-441-7329, Fax: 713-441-7438, Email:


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