Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

• Authors: Fransisca Leonard , Katherine Margulis , Xuewu Liu , Srimeenakshi Srinivasan , Shlomo Magdassi , Biana Godin
• Languages of publication: EN

Abstracts

EN

Ensuring drug loading efficiency and consistency is one of
the most critical stages in engineering drug delivery vectors
based on porous materials. Here we propose a technique
to significantly enhance the effciency of loading by
employing simple and widely available methods: applying
low pressure with and without centrifugation. Our results
point toward the advantages of the proposed method
over the passive loading, especially when the difference
between the dimensions of loaded materials and the pore
diameter is small, an increase of up to 20-fold can be observed.
The technique described in this study can be used
for efficient and reproducible loading of porous materials
with therapeutic molecules, nanoparticles and contrast
imaging agents for biomedical applications.

• Publisher: De Gruyter Open
• Journal: Mesoporous Biomaterials
• Year: 2014
• Volume: 1
• Issue: 1

Dates

online

29 - 5 - 2014

Contributors

author

Fransisca Leonard

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

author

Katherine Margulis

• Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
• Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA

author

Xuewu Liu

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

author

Srimeenakshi Srinivasan

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

author

Shlomo Magdassi

• Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

author

Biana Godin

• Houston Methodist Research Institute, Department of Nanomedicine, 6670 Bertner Ave, R7-122, Houston, TX 77030. Tel: [phone], Fax: [phone], Email:
  [e-mail]

References

• [1] Anglin, E.J., Cheng, L., Freeman, W.R., Sailor, M.J., 2008,Porous silicon in drug delivery devices and materials, AdvancedDrug Delivery Reviews 60, 1266-1277.[WoS][Crossref]
• [2] Arcos, D., López-Noriega, A., Ruiz-Hernández, E., Terasaki, O.,Vallet-Regí, M., 2009, Ordered mesoporous microspheres forbone grafting and drug delivery, Chemistry of Materials 21,1000-1009.[Crossref]
• [3] Bimbo, L.M., Sarparanta, M., Santos, H.A., Airaksinen, A.J.,Mäkilä, E., Laaksonen, T., et al., 2010, Biocompatibility ofthermally hydrocarbonized porous silicon nanoparticles andtheir biodistribution in rats, ACS Nano 4, 3023-3032.[WoS][Crossref]
• [4] Chiappini, C., Tasciotti, E., Fakhoury, J.R., Fine, D., Pullan, L.,Wang, Y.C., et al., 2010, Tailored porous silicon microparticles:Fabrication and properties, ChemPhysChem 11, 1029-1035.[Crossref][WoS]
• [5] Godin, B., Chiappini, C., Srinivasan, S., Alexander, J.F., Yokoi,K., Ferrari, M., et al., 2012, Discoidal porous silicon particles:Fabrication and biodistribution in breast cancer bearing mice,Advanced Functional Materials 22, 4225-4235.[WoS][Crossref]
• [6] Godin, B., Gu, J., Serda, R.E., Bhavane, R., Tasciotti, E., Chiappini,C., et al., 2010, Tailoring the degradation kinetics ofmesoporous silicon structures through PEGylation, Journal ofBiomedical Materials Research - Part A 94, 1236-1243.[WoS]
• [7] Godin, B., Tasciotti, E., Liu, X., Serda, R.E., Ferrari, M., 2011,Multistage nanovectors: From concept to novel imaging contrastagents and therapeutics, Accounts of Chemical Research44, 979-989.[WoS][Crossref]
• [8] Limnell, T., Santos, H.A., Mäkilä, E., Heikkilä, T., Salonen, J.,Murzin, D.Y., et al., 2011, Drug delivery formulations of orderedand nonordered mesoporous silica: Comparison of three drugloading methods, Journal of Pharmaceutical Sciences 100,3294-3306.[WoS][Crossref]
• [9] Liu, W., Liu, J., Yang, X., Wang, K., Wang, Q., Yang, M., et al.,2013, pH and ion strength modulated ionic species loadingin mesoporous silica nanoparticles, Nanotechnology 24,415501.[Crossref]
• [10] Low, S.P., Williams, K.A., Canham, L.T., Voelcker, N.H., 2006,Evaluation of mammalian cell adhesion on surface-modifiedporous silicon, Biomaterials 27, 4538-4546.[Crossref]
• [11] Mattos, C., Ringe, D., 2001, Proteins in organic solvents, CurrentOpinion in Structural Biology 11, 761-764.[PubMed][Crossref]
• [12] Prestidge, C.A., Barnes, T.J., Lau, C.H., Barnett, C., Loni, A.,Canham, L., 2007, Mesoporous silicon: A platform for thedelivery of therapeutics, Expert Opinion on Drug Delivery 4,101-110.[WoS][Crossref]
• [13] Salonen, J., Laitinen, L., Kaukonen, A.M., Tuura, J., Björkqvist,M., Heikkilä, T., et al., 2005, Mesoporous silicon microparticlesfor oral drug delivery: Loading and release of five modeldrugs, Journal of Controlled Release 108, 362-374.[Crossref]
• [14] Serda, R.E., Godin, B., Blanco, E., Chiappini, C., Ferrari, M.,2011, Multi-stage delivery nano-particle systems for therapeuticapplications, Biochimica et Biophysica Acta - GeneralSubjects 1810, 317-329.[WoS]
• [15] Srinivasan, S., Alexander, J.F., Driessen, W.H., Leonard, F.,Ye, H., Liu, X., et al., 2013, Bacteriophage associated siliconparticles: Design and characterization of a novel theranosticvector with improved payload carrying potential, Journal ofMaterials Chemistry B 1, 5218-5229.[WoS]
• [16] Tanaka, T., Godin, B., Bhavane, R., Nieves-Alicea, R., Gu, J.,Liu, X., et al., 2010, In vivo evaluation of safety of nanoporoussilicon carriers following single and multiple dose intravenousadministrations in mice, International Journal of Pharmaceutics402, 190-197.[WoS]
• [17] Tasciotti, E., Liu, X., Bhavane, R., Plant, K., Leonard, A.D.,Price, B.K., et al., 2008, Mesoporous silicon particles as amultistage delivery system for imaging and therapeutic applications,Nature Nanotechnology 3, 151-157.[WoS][Crossref]
• [18] Vallet-Regí, M., Balas, F., Arcos, D., 2007, Mesoporous materialsfor drug delivery, Angewandte Chemie - InternationalEdition 46, 7548-7558.[Crossref]
• [19] Vallet-Regi, M., Rámila, A., Del Real, R.P., Pérez-Pariente, J.,2001, A new property of MCM-41: Drug delivery system, Chemistryof Materials 13, 308-311.[Crossref]
• [20] Zendlová, L., Hobza, P., Kabelác, M., 2007, Stability of nucleicacid base pairs in organic solvents: Molecular dynamics,molecular dynamics/quenching, and correlated ab initiostudy, Journal of Physical Chemistry B 111, 2591-2609.[Crossref]

Identifiers

DOI

10.2478/mesbi-2014-0002