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2013 | 1 | 18-27

Article title

Immunometabolic role of leptin and adiponectin
in atherosclerosis: relationships with cardiovascular
complications in rheumatic diseases


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Patients with rheumatic diseases have an increased risk of mortality
by cardiovascular events. In fact, several rheumatic diseases such
as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus
and ankylosing spondylitis are associated with a higher prevalence of
cardiovascular diseases (CVDs). Although, traditional cardiovascular risk
factors have been involved in the pathogenesis of cardiovascular diseases
in rheumatic patients, these alterations do not explain completely the
enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to
an altered pattern of secretion of pro-inflammatory adipokines, could be
one of the links between cardiovascular and rheumatic diseases. Indeed,
the incidence of CVDs is augmented in obese individuals with rheumatic
disorders. Thus, in this review we explore in detail the relationships
among leptin and adiponectin with rheumatic diseases and cardiovascular
complications by giving to the reader a holistic vision and several
suggestions for future perspectives and potential clinical implications.







Physical description


14 - 11 - 2013


  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain
  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain
  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain
  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain
  • La Fe University Hospital,
    Valencia, Spain
  • La Fe University Hospital,
    Valencia, Spain
  • La Fe University Hospital,
    Valencia, Spain
  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain
  • Cellular and Molecular Cardiology
    Research Unit and Department of
    Cardiology of the Institute of Biomedical
    Research (IDIS) and University Clinical
    Hospital (CHUS-SERGAS), Santiago de
    Compostela, Spain


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