Immunometabolic role of leptin and adiponectin
in atherosclerosis: relationships with cardiovascular
complications in rheumatic diseases

• Authors: Sandra Feijóo-Bandín , Diego Rodríguez-Penas , Vanessa García-Rúa , Ana Mosquera-Leal , Esther Roselló-Lletí , Manuel Portolés , Miguel Rivera , José Ramón González-Juanatey , Francisca Lago
• Languages of publication: EN

Abstracts

EN

Patients with rheumatic diseases have an increased risk of mortality
by cardiovascular events. In fact, several rheumatic diseases such
as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus
and ankylosing spondylitis are associated with a higher prevalence of
cardiovascular diseases (CVDs). Although, traditional cardiovascular risk
factors have been involved in the pathogenesis of cardiovascular diseases
in rheumatic patients, these alterations do not explain completely the
enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to
an altered pattern of secretion of pro-inflammatory adipokines, could be
one of the links between cardiovascular and rheumatic diseases. Indeed,
the incidence of CVDs is augmented in obese individuals with rheumatic
disorders. Thus, in this review we explore in detail the relationships
among leptin and adiponectin with rheumatic diseases and cardiovascular
complications by giving to the reader a holistic vision and several
suggestions for future perspectives and potential clinical implications.

Keywords

EN

Adipokines ; Metabolism ; Cardiovascular disease ; Atherosclerosis

• Publisher: De Gruyter Open
• Journal: Immunometabolism
• Year: 2013
• Volume: 1
• Pages: 18-27

Dates

online

14 - 11 - 2013

Contributors

author

Sandra Feijóo-Bandín

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

author

Diego Rodríguez-Penas

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

author

Vanessa García-Rúa

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

author

Ana Mosquera-Leal

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

author

Esther Roselló-Lletí

• La Fe University Hospital,
  Valencia, Spain

author

Manuel Portolés

• La Fe University Hospital,
  Valencia, Spain

author

Miguel Rivera

• La Fe University Hospital,
  Valencia, Spain

author

José Ramón González-Juanatey

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

author

Francisca Lago

• Cellular and Molecular Cardiology
  Research Unit and Department of
  Cardiology of the Institute of Biomedical
  Research (IDIS) and University Clinical
  Hospital (CHUS-SERGAS), Santiago de
  Compostela, Spain

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Identifiers

DOI

10.2478/immun-2013-0004