The focus of this review paper is on the design
and implementation of smart ‘Sense-and-Treat’ systems
using enzyme-biocatalytic systems. These systems were
used to perform biomolecular computing and they were
functionally integrated with signal responsive materials
aiming towards their biomedical use. Electrode interfaces,
functionalized with signal-responsive materials,
find applications in biocomputing, biosensing, and,
specifically, triggered release of bioactive substances.
‘Sense-and-Treat’ systems require multiple components
working together, including biosensors, actuators, and
filters, in order to achieve closed-loop and autonomous
operation. In general, biochemical logic networks were
developed to process single biochemical or chemical
inputs as well as multiple inputs, responding to nonphysiological
(for concept demonstration purposes) and
physiological signals (for injury detection or diagnosis).
Actuation of drug-mimicking release was performed using
the responsive material iron-cross-linked alginate with
entrapped biomolecular species, responding to physical,
chemical or biochemical signals.