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2015 | 51 | 2 | 47-51

Article title

Preliminary Clinical Study On Ms Treatment With Hyperbaric Oxygenation

Content

Title variants

Languages of publication

EN

Abstracts

EN
The authors conducted the preliminary clinical investigation on 16 multiple sclerosis (Sclerosis multiplex) patients of median disease duration 9.33 years and symptoms evaluated on Kurtzke’s scale. The patients underwent between 25 and 30 hyperbaric oxygen exposures at a pressure of 2 ata in intervals spread over a few days. The patients were qualified and classified to the treatment symptomatologically according to Fisher but the obtained results were evaluated according to the standardised Disability Status Scale by Kurtzke. During the investigations the authors carried out additional quantitative immunoglobulin and complement activity determination, lymphocyte T and B determinations as well as the usually applied clinical and laboratory investigations. Evident clinical improvement was observed in 14 patients, but in the case of one patient a deterioration was observed after 15 hyperbaric expositions (resulting in the hyperbaric oxygen treatment being stopped), whilst in another case no curative effect could be observed. By utilising the 50% haemolysis method, within the examined immunological parameters the authors observed an increase of complement fractions and its activity, white lymphocytes T and B examined qualitatively did not maintain the characteristic shift. The authors are still discussing the obtained results.

Publisher

Year

Volume

51

Issue

2

Pages

47-51

Physical description

Dates

published
1 - 6 - 2015
online
18 - 11 - 2015
accepted
2 - 6 - 2014

Contributors

  • Department of Human Epidemiology and Ecology of the Institute of Clinical Medicine, Medical Academy of Cracow in Rzeszów, Maritime and Tropical Medicine Institute of Gdynia, Maritime Medicine Institute of the Warsaw Medical Academy in Gdynia, Poland
  • Department of Human Epidemiology and Ecology of the Institute of Clinical Medicine, Medical Academy of Cracow in Rzeszów, Maritime and Tropical Medicine Institute of Gdynia, Maritime Medicine Institute of the Warsaw Medical Academy in Gdynia, Poland
  • Department of Human Epidemiology and Ecology of the Institute of Clinical Medicine, Medical Academy of Cracow in Rzeszów, Maritime and Tropical Medicine Institute of Gdynia, Maritime Medicine Institute of the Warsaw Medical Academy in Gdynia, Poland
  • Department of Human Epidemiology and Ecology of the Institute of Clinical Medicine, Medical Academy of Cracow in Rzeszów, Maritime and Tropical Medicine Institute of Gdynia, Maritime Medicine Institute of the Warsaw Medical Academy in Gdynia, Poland
  • Department of Human Epidemiology and Ecology of the Institute of Clinical Medicine, Medical Academy of Cracow in Rzeszów, Maritime and Tropical Medicine Institute of Gdynia, Maritime Medicine Institute of the Warsaw Medical Academy in Gdynia, Poland

References

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  • 10. Gołowkin W.N., Zajcew W.S., Łotewin A.P. - Hiperbariczeskaja oxygenija kak immunostimulator pri Rassejanom Skleroze. Sow.Med.1985.2:22-26.
  • 11. Gozzano M. - Sclerosi e placche. Trattato delie malattie nervosa. IV.Ed. Valdi. 1970. pp.642-659.
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  • 15. Kurtzke J. - Further notes on disability evaluation in Multiple Sclerosis with scale modification. Neurol. 1965.15:654-661.[Crossref]
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  • 19. Neubauer R. - Treatment of Multiple Sclerosis with monoplace hyperbaric oxygenation. J.Fla.Med.Ass.1978.65:101-
  • 20. Pawelski S. - Laboratory diagnostics in haematology. PZWL. Warsaw. 1983. II. Ed. pp. 354-357 - Barbara Żupańska "Methods for lymphocyte determination in peripheral blood".
  • 21. Perrins D. - Hyperbaric, Oxygen for patients with Multiple Sclerosis. Brit. Med. J. 1984.288:1229-1230.
  • 22. Pugliese A., Missio C. - Ipotesi sull’eziologia della sclerosis multipla. Giorn. Batt. Virol. Immun. LXX. Luglio-Dicembre 1987:249-255.
  • 23. Rose A., Kuzma J., Kurtzke J. et al. - Cooperative study in evaluation of therapy in Multiple Sclerosis.: ACTH with Placebo in acute exacerbations. Preliminary report. Neurol. 1968. 18/ suppl./ :1-10.
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  • 25. Zannini D., Formai C., Bogetti B., Sereni G. - Osservazioni su 40 casi di sclerosi multipla trattati con ossigenoterapia iperbarica. Med. Subq. Ed Iperb. 1982.2.1:1-7.
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_phr-2015-0010
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