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2014 | 10 | 1 |

Article title

The pharmacological research of Tek-1 relevance to anti-neuroinflammation, a candidate compound based on Telmisartan


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In this paper, BV-2 mouse small glial cell inflammation model induced by LPS is established. The experiment used 0.1-10 μM of telmisartan and Tek-1 to incubate with small glial cell and used telmisartan and Tek-1 to incubate with PPAR gamma special heterosexual antagonistic anti-agent GW9662. The article used ELISA method to dectect TNF-a effect on small glial cell for telmisartan and Tek-1. The article used real-time quantitative PCR method to dectect mRNA level expression effect of CD11b, CD16 and iNOS on small glial cell for telmisartan and Tek-1 and used Western Blot method to dectect MAPKs signal pathway and NF-κb signal turned guide pathway effect on small glial cell for telmisartan and Tek-1. Results show that Tek-1 had high affinity with AT1 receptor and inhibited intracellular calcium ion activation which can be for the AT1 receptor antagonists. Meanwhile, Tek-1 can partially activate PPAR gamma compared with full agonists of rosiglitazone.








Physical description


1 - 1 - 2015
10 - 7 - 2015
14 - 10 - 2015
17 - 12 - 2015


  • Department of Neurology, Xian Jiao Tong University, Postal code 710061, China
  • Department of Vasculocardiology, Xian Jiao Tong University, Postal code 710061, China


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