The pharmacological research of Tek-1 relevance to anti-neuroinflammation, a candidate compound based on Telmisartan

• Authors: Jianbo Yang , Changcong Cui
• Languages of publication: EN

Abstracts

EN

In this paper, BV-2 mouse small glial cell inflammation model induced by LPS is established. The experiment used 0.1-10 μM of telmisartan and Tek-1 to incubate with small glial cell and used telmisartan and Tek-1 to incubate with PPAR gamma special heterosexual antagonistic anti-agent GW9662. The article used ELISA method to dectect TNF-a effect on small glial cell for telmisartan and Tek-1. The article used real-time quantitative PCR method to dectect mRNA level expression effect of CD11b, CD16 and iNOS on small glial cell for telmisartan and Tek-1 and used Western Blot method to dectect MAPKs signal pathway and NF-κb signal turned guide pathway effect on small glial cell for telmisartan and Tek-1. Results show that Tek-1 had high affinity with AT1 receptor and inhibited intracellular calcium ion activation which can be for the AT1 receptor antagonists. Meanwhile, Tek-1 can partially activate PPAR gamma compared with full agonists of rosiglitazone.

Keywords

EN

Cartilage rhinoplasty; Goldman technique; Broad nasal tip; Dome-splitting

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

published

1 - 1 - 2015

received

10 - 7 - 2015

accepted

14 - 10 - 2015

online

17 - 12 - 2015

Contributors

author

Jianbo Yang

• Department of Neurology, Xian Jiao Tong University, Postal code 710061, China

author

Changcong Cui

• Department of Vasculocardiology, Xian Jiao Tong University, Postal code 710061, China

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Identifiers

DOI

10.1515/med-2015-0077