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2014 | 10 | 1 |

Article title

Is cognitive processing affected in adults with hypospadias?: P300 study


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Background: Hypospadias is a common urogenital
system disorder. The frenulum, which is the most
sensitive area of the glans penis, is not present in patients
with hypospadias. This may lead to a failure in sexual
and ejaculatory function, and cause emotional problems
affecting cognitive processes. Aim: We aimed to study auditory Event Related Potentials
(ERP) in patients with hypospadias to understand the
status of cognitive function. Materials and Methods: Seventeen patients with hypospadias
who presented to the Urology Outpatient Clinic
of Çanakkale Military Hospital, and 11 healthy individuals
of similar age were chosen. The auditory oddball paradigm
with ERP from the Cz and Fz head regions were
studied. The latency and amplitude of the P300 wave were
measured. Results: Both, the study and control groups consisted of
young males. Although the study group had a longer P300
latency and lower P300 amplitude when compared to control group, the results were not statistically significant
(p: 0.059 and 0.346 respectively). Conclusion: Although the results are not statistically significant,
our findings indicate that there may be cognitive
changes in patients with hypospadias. Further studies of
larger sample size and older patient cohorts are needed.








Physical description


14 - 9 - 2015
18 - 1 - 2015
26 - 10 - 2015


  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Neurology, Istanbul, Turkey
  • Gölcük Asker Hastanesi, Department of Urology,
    Kocaeli, Turkey
  • Çanakkale Onsekiz Mart Üniversitesi,
    Department of Urology, Çanakkale, Turkey
  • Okmeydani Education
    and Research Hospital Neurology Clinic Kaptanpasa Mahallesi
    Darülaceze Street No: 25 ZIP Code: 34384, Sisli, Istanbul, Turkey
  • Okmeydanı Eğitim Araştırma Hastanesi,
    Department of Neurology, İstanbul, Turkey
  • Ankara Mevki Asker Hastanesi, Department of Neurology,
    Ankara, Turkey
  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Urology, Istanbul, Turkey
  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Neurology, Istanbul, Turkey
  • Çanakkale
    Onsekiz Mart Üniversitesi, Department of Neurology., Çanakkale,
  • Çanakkale Onsekiz Mart Üniversitesi,
    Department of Urology, Çanakkale, Turkey
  • Çanakkale
    Onsekiz Mart Üniversitesi, Department of Neurology., Çanakkale,


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