PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2014 | 10 | 1 |
Article title

Is cognitive processing affected in adults with hypospadias?: P300 study

Content
Title variants
Languages of publication
EN
Abstracts
EN
Background: Hypospadias is a common urogenital
system disorder. The frenulum, which is the most
sensitive area of the glans penis, is not present in patients
with hypospadias. This may lead to a failure in sexual
and ejaculatory function, and cause emotional problems
affecting cognitive processes. Aim: We aimed to study auditory Event Related Potentials
(ERP) in patients with hypospadias to understand the
status of cognitive function. Materials and Methods: Seventeen patients with hypospadias
who presented to the Urology Outpatient Clinic
of Çanakkale Military Hospital, and 11 healthy individuals
of similar age were chosen. The auditory oddball paradigm
with ERP from the Cz and Fz head regions were
studied. The latency and amplitude of the P300 wave were
measured. Results: Both, the study and control groups consisted of
young males. Although the study group had a longer P300
latency and lower P300 amplitude when compared to control group, the results were not statistically significant
(p: 0.059 and 0.346 respectively). Conclusion: Although the results are not statistically significant,
our findings indicate that there may be cognitive
changes in patients with hypospadias. Further studies of
larger sample size and older patient cohorts are needed.
Publisher
Journal
Year
Volume
10
Issue
1
Physical description
Dates
accepted
14 - 9 - 2015
received
18 - 1 - 2015
online
26 - 10 - 2015
References
  • [1] Dodds PR, Batter SJ, Shield DE, Serels SR, Garafalo FA, MaloneyPK. Adaptation of adults to uncorrected hypospadias; Urology2008; 71: 682-685[WoS][Crossref]
  • [2] Karademir K, Akyol İ, Adayener C. Effects of hypospadias onpsychosexual functions. Bulletin of Andrology 2006 December;p308–310 (Turkish)
  • [3] Hunt N, McHale S. Psychosocial aspects of andrologic disease.Endocrinol Metab Clin N Am 2007; 36:521–531
  • [4] Oken B. Endogenous event-related potentials, in Chiappa KH(Ed): Evoked Potentials in Clinical Medicine. Philadelphia,Lippincott-Raven, 1987, pp 529–563
  • [5] Goodin DS. Event related (endogenous) potentials. In: AminoffMJ editors. Electrodiagnosis in Clinical Neurology. New York:Churchill Livingstone; 1992; p. 627–648
  • [6] Picton, T. W. and Hillyard, S. A.: Endogenous event-relatedpotentials. In: Human Event-Related Potentials. EEG Handbook,revised series. Edited by T. W. Picton. New York: Elsevier, vol. 3,1989; p. 361
  • [7] Duncan CC, Barry RJ, Connolly JF, Fischer C, Michie PT, NäätänenR et al. Event-related potentials in clinical research: guidelinesfor eliciting, recording, and quantifying mismatch negativity,P300, and N400. Clin Neurophysiol. 2009; 120(11):1883-1908[WoS]
  • [8] Maria José Santos Cóser. P300 Auditory Evoked PotentialLatency In Elderly. Braz J Otorhinolaryngol 2010;76: 287-293
  • [9] Iacono WG, McGue M. Association between P3 event-relatedbrain potential amplitude and adolescent problem behavior.Psychophysiology. 2006; 43(5):465-469[Crossref]
  • [10] Vardi Y, Sprecher E, Gruenwald I, Yarnitsky D, Gartman I,Granovsky Y. The p300 event-related potential technique forlibido assessment in women with hypoactive sexual desiredisorder. J Sex Med 2009; 6: 1688–1695[WoS][Crossref]
  • [11] Vardi Y, Volos M, Sprecher E, Granovsky Y, Gruenwald I,Yarnitsky D. A p300 event related potential technique forassessment of sexually oriented interest. The Journal ofUrology 2006; 176; 2736–2740
  • [12] Knight RT. Electrophysiological methods in behavioralneurology and neurophysychology. In: Feinberg TE, Farah MJeditor. Behavioral Neurology and Neurophysychology. NewYork: McGraw Hill; 1997; p. 101–119
  • [13] Polich J, Herbst KL. P300 as a clinical assay (rationale,evaluation, and findings). Int J Psychophysiol. 2000; 38: 3–19[Crossref]
  • [14] Ozcan C, Ozbek E, Soylu A, Yilmaz U, Guzelipek M, Balbay DM.Auditory event-related potentials in patients with prematureejaculation. The Journal of Urology 2001; 58: 1025–1029
  • [15] Maretti MB, Haddad AS, Ferreira MC, Guaré Rde O, Alonso LG.Toriello Carey syndrome: genetic, clinical, and oral considerations:a case report. Spec Care Dentist. 2011 31: 68–72
  • [16] Golabi M, James AW, Good WV, Cotter PD. Tissue-limitedmosaicism for monosomy 13. Am J Med Genet A. 2010;152A(10): 2634–2639[WoS]
  • [17] Climent Alcalá FJ, Molina Rodríguez MA, González Casado I,Osona Bris L, Salamanca Fresno L, Guerrero-Fernández J, et al.Chromosome 9P deletion: Gonadal dysgenesis associated withmental retardation and hypoplasia of the corpus callosum: Acontiguous gene syndrome? An Pediatr (Barc). 2010 Mar;72:210–214
  • [18] Hoffman LD, Polich J. P300, handedness, and corpus callosalsize: gender, modality, and task. Int J Psychophysiol. 1999; 31:163–174[Crossref]
  • [19] Polich J, Hoffman LD. P300 and handedness: on the possiblecontribution of corpus callosal size to ERPs. Psychophysiology.1998; 35: 497–507
  • [20] Nager W, Krauss JK, Heldmann M, Marco-Pallares J, CapelleHH, Lütjens G et al. Human hypothalamus shows differentialresponses to basic motivational stimuli-an invasive electrophysiologystudy. Neuroscience. 2011 25;189:330–336[WoS]
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_med-2015-0059
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.