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2015 | 28 | 3 | 204-207
Article title

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

Content
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Languages of publication
EN
Abstracts
EN
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.
Publisher

Year
Volume
28
Issue
3
Pages
204-207
Physical description
Dates
published
1 - 9 - 2015
received
2 - 7 - 2015
accepted
20 - 8 - 2015
online
26 - 11 - 2015
Contributors
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
author
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland, jarogniew.luszczki@gmail.com
  • Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0073
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