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Number of results
2015 | 28 | 3 | 204-207

Article title

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

Content

Title variants

Languages of publication

EN

Abstracts

EN
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

Publisher

Year

Volume

28

Issue

3

Pages

204-207

Physical description

Dates

published
1 - 9 - 2015
received
2 - 7 - 2015
accepted
20 - 8 - 2015
online
26 - 11 - 2015

Contributors

  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
author
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0073
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