Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

• Authors: Aleksandra Wlaz , Maria W. Kondrat-Wrobel , Katarzyna Zaluska , Ewelina Kochman , Anna R. Rekas , Jarogniew J. Luszczki
• Languages of publication: EN

Abstracts

EN

This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

Keywords

EN

6 Hz psychomotor seizure model; antiepileptic drugs; drug interactions; gabapentin; levetiracetam; isobolographic analysis

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2015
• Volume: 28
• Issue: 3
• Pages: 204-207

Dates

published

1 - 9 - 2015

received

2 - 7 - 2015

accepted

20 - 8 - 2015

online

26 - 11 - 2015

Contributors

author

Aleksandra Wlaz

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland

author

Maria W. Kondrat-Wrobel

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland

author

Katarzyna Zaluska

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland

author

Ewelina Kochman

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland

author

Anna R. Rekas

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland

author

Jarogniew J. Luszczki

• Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
• Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland

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Identifiers

DOI

10.1515/cipms-2015-0073