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Article title

Dissolution behavior and cell compatibility of
alkali-free MgO-CaO-SrO-TiO2-P2O5 glasses for
biomedical applications

Content
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EN
Abstracts
EN
Owing to their controlled solubility, phosphate
invert glasses are of interest for use as temporary implant
materials or tissue engineering scaffolds for controlled
ion release.MgO-CaO-SrO-TiO2-P2O5 invert glasses
were prepared and their dissolution behavior and cell response
were examined.MgO addition to the phosphate invert
glass system improved glass formation, owing to the
relatively large field strength of Mg2+ ions. In osteoblastlike
MC3T3-E1 cell culture tests, cell numbers on the invert
glasses were significantly larger compared with the
control, possibly caused by the release of Mg2+ ions promoting
enhanced cell adhesion and proliferation. Alkaline
phosphatase (ALP) activity varied with glass composition,
with higher strontium for calcium substitution (33
to 100%) showing highest ALP activity. This effect may be
caused by the release of strontium ions from the glasses.
Publisher
Year
Volume
1
Issue
1
Physical description
Dates
online
18 - 12 - 2015
accepted
2 - 10 - 2015
received
4 - 8 - 2015
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_bglass-2015-0015
Identifiers
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