Dissolution behavior and cell compatibility of
alkali-free MgO-CaO-SrO-TiO2-P2O5 glasses for
biomedical applications

• Authors: Sungho Lee , Akiko Obata , Delia S. Brauer , Toshihiro Kasuga
• Languages of publication: EN

Abstracts

EN

Owing to their controlled solubility, phosphate
invert glasses are of interest for use as temporary implant
materials or tissue engineering scaffolds for controlled
ion release.MgO-CaO-SrO-TiO2-P2O5 invert glasses
were prepared and their dissolution behavior and cell response
were examined.MgO addition to the phosphate invert
glass system improved glass formation, owing to the
relatively large field strength of Mg2+ ions. In osteoblastlike
MC3T3-E1 cell culture tests, cell numbers on the invert
glasses were significantly larger compared with the
control, possibly caused by the release of Mg2+ ions promoting
enhanced cell adhesion and proliferation. Alkaline
phosphatase (ALP) activity varied with glass composition,
with higher strontium for calcium substitution (33
to 100%) showing highest ALP activity. This effect may be
caused by the release of strontium ions from the glasses.

Keywords

EN

Phosphate glass; magnesium; calcium; strontium; ion release; cell response; MC3T3-E1

• Publisher: De Gruyter Open
• Journal: Biomedical glasses
• Year: 2015
• Volume: 1
• Issue: 1

Dates

online

18 - 12 - 2015

accepted

2 - 10 - 2015

received

4 - 8 - 2015

Contributors

author

Sungho Lee

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

author

Akiko Obata

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

author

Delia S. Brauer

• Otto Schott Institute of Materials Research,
  Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena,
  Germany

author

Toshihiro Kasuga

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

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Identifiers

DOI

10.1515/bglass-2015-0015