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A metastatic gastric cancer mimicking a chronic myeloproliferative disorder

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Beyan E., Beyan C.
Open Medicine
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2010
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vol. 5
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issue 1
140-143
EN
It is known that coexistence of extreme thrombocytosis and thrombosis is observed frequently in chronic myeloproliferative disorders. In this paper, we report a patient who was prediagnosed with chronic myeloproliferative disorder; however, later on the diagnosis was confirmed as metastatic gastric cancer. The patient was a 75-year old female who was admitted with pain, swelling and erythema on her right arm. White blood cell count was 20 ×109/l, hemoglobin 5.2 g/dl and platelet count 1 088 ×109/l. Doppler ultrasonography revealed acute thrombotic process in right brachial vein. Since brachial vein thrombosis, thrombocytosis and anemia were seen together, the presumed diagnosis for this patient was chronic myeloproliferative disorder, and therapy with hydroxyurea, allopurinol and enoxaparin was started. One day after the heparin treatment, hematemesis and melena occurred. Eusophagogastroduodenal endoscopy showed an ulcerated and hemorrhagic polipoid lesion extending towards the cavity in the cardia region. Hydroxyurea treatment was stopped since the myeloproliferative disorder was excluded. Abdominal ultrasonography and tomography proved multiple metastatic lesions in the liver. Gastric and liver biopsies revealed “well differentiated adenocarcinoma” and 5-fluorouracil chemotherapy plus folinic acid was planned. As a result, in cases with thrombocytosis and thrombosis, metastatic cancers should be kept in mind besides chronic myeloproliferative disorders.
2
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Severe renal vascular hypertension caused by upper left branch renal artery stenosis complicated with multiple thrombosis and cardiac hypertrophy

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Milošević D., Batinić D., Hodžić S., Lemac M., Spajić M., Turudić D., Potkonjak A.-M.
Open Medicine
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2014
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vol. 9
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issue 3
443-445
EN
A severe hypertension was found in a 9 month old boy with signs and symptoms of severe arterial hypertension. An upper left branch renal artery stenosis complicated with multiple thrombosis and cardiac hypertrophy was diagnosed. Surgical heminephrectomy of the upper pole of the left kidney was successful in blood pressure normalization with significant improve of cardiac function and thrombosis recanalization.
3
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In vitro hemocompatibility and corrosion behavior of new Zr-binary alloys in whole human blood

100%
Totea G., Ionita D., Demetrescu I., Mitache M.
Open Chemistry
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2014
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vol. 12
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issue 7
796-803
EN
The aim of this study is to evaluate the accuracy of three binary alloys’ composition, and their biocompatibility. Depending on the intended use of the medical devices made from these materials, dynamic or static tests should be performed. We have chosen static tests as we thought they may be used as knee or hip replacement, and not as cardiac valves. Three binary alloys ( Zr10Nb, Zr2.5Nb and Zr12Ta) were obtained from high purity powders (>99.9%), using an induction furnace first, and an electric arc furnace for a perfect homogenization. Their final composition was verified with a XRF analyzer-INNOV-X. Hemolysis tests can determine the degree of red blood cells lysis and the release of hemoglobin. The released hemoglobin quantity was extremely small, under 2%, in all cases, and the coagulation tests showed no risk for thrombosis. The electrochemical behavior was also studied in biological fluid, human female serum, and showed a low corrosion rate. The obtained alloys do not cause hemolysis, so they are hemocompatible with all blood types.
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