Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 3

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  METALLOPROTEASE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Matrix metalloproteases (MMPS)

100%
Gacko M.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
|
vol. 51
|
issue 5
577-589
EN
Matrix metalloproteases (MMPs) are synthesized in the form proenzymes. They are activated in the process of limited proteolysis and non-enzymatically by active forms of oxygen. Activity of these enzymes is controlled by tissue inhibitors of metalloproteases (TIMPs).
2

Mechanisms of activation, biological role and inhibitors of metalloproteases of extracellular matrix

100%
Gacko M.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
|
vol. 55
|
issue 2
303-318
EN
Prometalloproteases are activated by serine proteases, MMP-3, leucocytic elastase, furin, furin-like proteases and by membrane-type metalloproteases as well. They form complex with some proMMPs and thus they modify their activation.
3
Content available remote

Laminin promotes oligogliogenesis and increases MMPs activity in human neural stem cells of HUCB-NSC line

88%
Sypecka J., Dragun-Szymczak P., Zalewska T., Domanska-Janik K.
Acta Neurobiologiae Experimentalis
|
2009
|
vol. 69
|
issue 1
37-45
EN
Oligodendrocytes, the cells responsible for myelin formation and maintenance in CNS, are depleted in many acute and chronic conditions. The stem/progenitor cells stimulation or transplantation might be seriously considered as a long hoped for therapeutic perspective. Better understanding of the mechanism(s) regulating the activation of the cell lineage from the endogenous progenitor reservoir might be helpful. Therefore an efficient source of donor cells for transplantation in humans is being craved for. In this study we show that the application of extracellular matrix component-laminin promotes oligogliogenesis from neural stem-like cells of human cord blood cells (HUCB-NSC). Although oligodendrocytes constitute a minor subpopulation of spontaneously differentiated HUCB-NSC, the manipulation of active compounds regulating the process of cell commitment results in a several fold increase in their number. Thus cells of the HUCB-NSC line could be considered as a potential source of glial cells, fulfilling the suitable candidate criteria for oligodendrocyte replacement therapy.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.