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RNAi in therapy

100%

Kubiak K., Nawrot B.

Biotechnologia

2009

issue 1

132-151

The discovery of RNA interference caused a revival of the concept of short nucleic acids application as molecular tools for therapeutic control of gene expression. After almost a decade of intensive research by leading pharmaceutical companies, there is only a limited number of clinical trials of synthetic siRNAs. In this review, we shall summarize the present status of knowledge of RNAi mechanism of action and discuss the potential of the use of siRNA in theraphy. We shall also provide data on recent achievements in current clinical trials based on RNAi techniques.

An optimization of esters synthesis catalysed by Mucor javanicus T45 lipase in non-water media

75%

Antczak T., Galas E.

Biotechnologia

1995

issue 2

73-81

An optimization of enzymatic synthesis of esters in nonwater environment was performedby mens of a gradient method.The studies were aimed at obtaining a model synthesis of butyl oleate catalyzed by Mucor javanicus T45 lipase.Theoptimized, changed parameters were as follows:substrated mass, lipase mass and chemical activator mass (diethanoloamine) which profitably modified the essential water layer of the lipase.For the initial concentration of the substrates equal to 57-67%, in reaction environment the obtained yield of coversion of oleic acid was in the range of 90-95%. A transfer of optimized conditions of butyl oleate synthesis onto oleates of the other aliphatic alcohols, enabled elaboration of simple in performance methods of synthesisof a broad variety of esters of oleic acid and aliphatic alcohols (C2-C18).

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2 Biotechnologia

1 2009

1 1995

1 Antczak T.

1 Galas E.

1 Kubiak K.

1 Nawrot B.

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RNAi in therapy

An optimization of esters synthesis catalysed by Mucor javanicus T45 lipase in non-water media