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1

The NFB/IB system in acute inflammation

100%
Lentsch A. B., Ward P. A.
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vol. 48
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issue 2
59-63
EN
The transcription factor NFkappaB is a primary regulator of a wide variety of proinflammatory mediators. Under normal conditions, NFkappaB is retained in the cytoplasm bound to inhibitory proteins of the I kappaB family. Following cell activation, a number of signal transduction pathways lead to degradation of I kappaB proteins which results in nuclear translocation of NFkappaB and the ensuing transcriptional activation of proinflammatory genes. Several endogenous regulatory mediators, which function to prevent uncontrolled inflammation, exert their effects by blocking the activation of NFkappaB. Thus, NFkappaB appears to be at the heart of the acute inflammatory response. The present review discusses the role of NFkappaB in the induction and propagation of the acute inflammatory response as well as the regulation and resolution of this process.
2

Analysis of peritoneal and head kidney phagocytes during Thioglycollate-elicited peritoneal inflammation in the goldfish, Carassius auratus

86%
Gruca P., Chadzinska M., Lackowska B., Plytycz B.
Folia Biologica
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1996
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vol. 44
137-142
EN
Intraperitoneal injection of goldfish with Thioglycollate induced an acute peritoneal inflammation connected with an influx of leucocytes. The number and some properties (migratory activity, PMA-induced chemiluminescence) of leucocytes were analysed in parallel in suspensions of peritoneal and head kidney (HK) leucocytes. It was found that the increased number of peritoneal large granular cells corresponds with the decreased number of such leucocytes in HK. Moreover, the enhancement of migratory and chemiluminescent activity of peritoneal leucocytes corresponds with the inhibition of these activities in head kidney cells. The results strongly indicate that the head kidney, the major lymphomyeloid organ of teleosts, is the main source of leucocytes inhabiting the peritoneal cavity following induction of an acute inflammation.
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