PHYSICOCHEMICAL CHARACTERIZATION AND DISSOLUTION STUDIES OF SOLID DISPERSIONS OF CLOTRIMAZOLE WITH CHITOSAN

• Authors: Bożena Grimling , Justyna Jasińska , Jan Meler , Maria Szcześniak , Janusz M. Pluta , Agata Górniak
• Languages of publication: EN

Abstracts

EN

The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.

Keywords

EN

FTIR; XRPD; chitosan; clotrimazole; solid dispersion

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2016
• Volume: 21
• Pages: 63-72

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

author

Justyna Jasińska

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

author

Jan Meler

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

author

Maria Szcześniak

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

author

Janusz M. Pluta

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

author

Agata Górniak

• Faculty of Pharmacy, Laboratory of Elemental Analysis and Structural Research The „Silesian Piasts” memorial Medical University of Wroclaw St. Borowska 211a, 50-556 Wroclaw Poland

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• Document Type: article