THE PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol resulted in increased pH of the formulations. A modification of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol has increased the range of the dynamic viscosity of formulations. The enrichment of the composition of the tested powders containing 5% hydroxypropylmethylcellulose resulted in increased the range of the dynamic viscosity and decreased pH of the formulations. Laboratory tests have shown that it is possible to obtain thermosensitive gels with high adhesion properties to vaginal mucous membrane.

Keywords

EN

anti-inflammatory drugs; lactic acid complexed with chitosan; physiological environment of vagina; thermosensitive hydrophilic powders passing gels; vaginal infections; vaginal mucosa

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2015
• Volume: 20
• Pages: 183-194

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy, The “Silesian Piasts” memorial Medical University of Wroclaw, ul. Borowska 211A, 50-556 Wrocław, Borowska 211A Street, Poland

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• Document Type: article