Sugar Substitutes/Artificial Sweeteners: Benefits Vs Health Issues, and Alternatives

• Authors: Sarah A. Evbuomwan
• Languages of publication: EN

Abstracts

EN

The meals we eat every day contain sugar, which is an essential component. It is a soluble carbohydrate with a sweet flavor that imparts sweetness to food. Sugar consumption has been linked to health problems like cavities, weight gain, inflammation, diabetes, obesity, etc. As a result, using artificial sweeteners in place of sugar is now possible. Food additives known as artificial sweeteners work similarly to sugar but have less nutritional value. Saccharin, sucralose, aspartame, and acesulfame-K are a few examples. Artificial sweeteners can help with weight loss, diabetic management, dental decay prevention, cost savings, and other therapeutic and non-therapeutic benefits. However, research has also revealed that some health issues are associated with even these artificial sweeteners. Obesity, allergic reactions including hives and swellings, metabolic acidosis, and cancer are a few of these disorders. Additionally, it could encourage flatulence, nausea, and diarrhea. The purpose of this study is to examine the advantages and health implications of using artificial sugar substitutes as well as substitutions for them. It also supports the need for additional investigation to determine the precise mechanisms of action of these sugar substitutes employing in vitro, animal, and human models.

Keywords

EN

Artificial sweeteners; Natural sweeteners; Sugar; Sugar substitutes

Discipline

• BIOCHEMISTRY: BIOCHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2023
• Volume: 50
• Pages: 86-97

Contributors

author

Sarah A. Evbuomwan

• Department of Biochemistry, Covenant University, Km 10, Idiroko Road, Sango Ota, Ogun State, Nigeria

References

• [1] FDA No Calories. Sweet! Available from: http://www.fda.gov/fdac/features/2006/406_sweeteners.html. [Last accessed on 2011 Feb 1].
• [2] Tandel, K. R. (2011). Sugar substitutes: Health controversy over perceived benefits. Journal of Pharmacology & Pharmacotherapeutics, 2(4), 236
• [3] Pang MD, Goossens GH, Blaak EE. The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis. Front Nutr. 2021 Jan 7;7:598340. doi: 10.3389/fnut.2020.598340
• [4] Wurtman RJ. and Mahe TJ. Effects of aspartame on the brain: Neurologic effects of aspartame. Presented at the symposium: “Sweeteners: Health Effects,”. New York: Naylor-Dana Foundation; l987. p. 18-20
• [5] Mooradian, A. D., Smith, M., & Tokuda, M. (2017). The role of artificial and natural sweeteners in reducing the consumption of table sugar: A narrative review. Clinical Nutrition ESPEN, 18, 1–8. https://doi.org/10.1016/j.clnesp.2017.01.004
• [6] Markle N. Contra Aspartam. Available from: http://www.ever.ch/medizinwissen/aspartam.php. [Last accessed on 2011 June 2].
• [7] Castro-Muñoz, R., Correa-Delgado, M., Córdova-Almeida, R., Lara-Nava, D., Chávez-Muñoz, M., Velásquez-Chávez, V. F., ... & Ahmad, M. Z. (2022). Natural sweeteners: Sources, extraction and current uses in foods and food industries. Food Chemistry, 370, 130991
• [8] Ardalan, M. R., Tabibi, H., Attari, V. E., & Mahdavi, A. M. (2017). Nephrotoxic effect of aspartame as an artificial sweetener: A brief review. Iranian Journal of Kidney Diseases, 11(5), 339
• [9] Choudhary, A. K., & Pretorius, E. (2017). Revisiting the safety of aspartame. Nutrition Reviews, 75(9), 718–730
• [10] D. Muriel, J. O., Jean-Louis, K. K., Rebecca, R. A., & Ysidor, K. N. (2019). Development of a Method to Produce Granulated Sugar from the Inflorescences Sap of Coconut (Cocos nucifera L.) in Ivory Coast: Case of Hybrid PB113+. Journal of Experimental Agriculture International, 39(2), 1–9. https://doi.org/10.9734/jeai/2019/v39i230331
• [11] Asghar, M. T., Yusof, Y. A., Mokhtar, M. N., Ya’acob, M. E., Mohd. Ghazali, H., Chang, L. S., & Manaf, Y. N. (2020). Coconut (Cocos nucifera L.) sap as a potential source of sugar: Antioxidant and nutritional properties. Food Science and Nutrition, 8 (4), 1777–1787. https://doi.org/10.1002/fsn3.v8.410.1002/fsn3.1191
• [12] Nur Irma Izzati Muhammad & Norizah M. Sarbon (2023) Physicochemical profile, antioxidant activity and mineral contents of honey from stingless bee and honey bee species, Journal of Apicultural Research, 62:2, 394-401, DOI: 10.1080/00218839.2021.1896214
• [13] Saritha Vara, Manoj Kumar Karnena, Bhavya Kavitha Dwarapureddi. 6 - Natural Preservatives for Nonalcoholic Beverages, Editor(s): Alexandru Mihai Grumezescu, Alina Maria Holban, Preservatives and Preservation Approaches in Beverages, Academic Press, 2019, Pages 179-201, ISBN 9780128166857, https://doi.org/10.1016/B978-0-12-816685-7.00006-9
• [14] Swiąder, K., Wegner, K., Piotrowska, A., Fa-Jui, T., & Sadowska, A. (2019). Plants as a source of natural high-intensity sweeteners: A review. Journal of Applied Botany and Food Quality, 92, 160–171
• [15] Pandey, A. K., & Chauhan, O. P. (2019). Monk fruit (Siraitia grosvenorii)—Health aspects and food applications. Pantnagar J. Res 17, 191–198
• [16] Liu, C., Dai, L., Liu, Y., Dou, D., Sun, Y., & Ma, L. (2018). Pharmacological activities of mogrosides. Future Medicinal Chemistry, 10(8), 845–850
• [17] Zhou, G., Zhang, Y., Li, Y., Wang, M., & Li, X. (2018). The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats. Journal of Chromatography B, 1079, 25–33
• [18] Mellado-mojica, E., Seeram, N. P., & Lopez, ´ M. G. (2016). Comparative analysis of maple syrups and natural sweeteners: Carbohydrates composition and classification (differentiation) by HPAEC-PAD and FTIR spectroscopy-chemometrics. Journal of Food Composition and Analysis, 52, 1–8. https://doi.org/10.1016/j.jfca.2016.07.001
• [19] Mora, M. R., & Dando, R. (2021). The sensory properties and metabolic impact of natural and synthetic sweeteners. Comprehensive Reviews in Food Science and Food Safety, 20 (2), 1554–1583
• [20] Hampton T. Sugar substitutes linked to weight gain. JAMA 2008; 299: 2137-8
• [21] The Calorie Control Council.mht. [Last accessed on 2011 Feb 10].
• [22] Daniel JW, Renwick AG, Roberts A, Sims J. The metabolic fate of sucralose in rats. Food Chem Tox 2000; 38: 115-21
• [23] Cadirci, K., Tozlu, Ö. Ö., Türkez, H., & Mardinoğlu, A. (2020). The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells. Turkish Journal of Medical Sciences, 50(2), 448-454
• [24] Tsakiris, S., Giannoulia-Karantana, A., Simintzi, I., & Schulpis, K. H. (2006). The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity. Pharmacological Research, 53(1), 1-5
• [25] Yin, K. J., Xie, D. Y., Zhao, L., Fan, G., Ren, J. N., Zhang, L. L., & Pan, S. Y. (2020). Effects of different sweeteners on behavior and neurotransmitters release in mice. Journal of Food Science and Technology, 57, 113-121
• [26] Al-Eisa, R. A., Al-Salmi, F. A., Hamza, R. Z., & El-Shenawy, N. S. (2018). Role of L-carnitine in protection against the cardiac oxidative stress induced by aspartame in Wistar albino rats. PloS One, 13(11), e0204913
• [27] Kim, J. Y., Seo, J., & Cho, K. H. (2011). Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia. Food and Chemical Toxicology, 49(11), 2899-2905
• [28] Saucedo-Vence, K., Elizalde-Velázquez, A., Dublán-García, O., Galar-Martínez, M., Islas-Flores, H., SanJuan-Reyes, N., ... & Gómez-Oliván, L. M. (2017). Toxicological hazard induced by sucralose to environmentally relevant concentrations in common carp (Cyprinus carpio). Science of the Total Environment, 575, 347-357
• [29] Eriksson Wiklund, A. K., Adolfsson-Erici, M., Liewenborg, B., & Gorokhova, E. (2014). Sucralose induces biochemical responses in Daphnia magna. PloS One, 9(4), e92771. doi: 10.1371/journal.pone.0092771

• Document Type: article