An unusual presentation of corneal intraepithelial neoplasia

• Authors: Paula Marticorena-Álvarez , Guadalupe Garrido Ceca , Diego Asensio Celdrán Vivancos
• Languages of publication: EN

Abstracts

EN

Introduction: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion. Clinical case: An 80-year-old woman with an elevated, avascular, well-demarcated grey corneal plaque. After epitheliectomy and alcohol, the excised lesion was identified as a high-grade epithelial neoplasia. Treatment was topical interferon α-2b for 1 month without recurrences. Conclusions: A well-defined greyish corneal opacity should always raise suspicion of an intraepithelial neoplasia. In the present case, epitheliectomy and topical recombinant interferon proved successful.

Keywords

EN

cornea; epitheliectomy; interferon; intraepithelial; neoplasia

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OphthaTherapy
• Year: 2020
• Volume: 7
• Issue: 4
• Pages: 302-304

Contributors

author

Paula Marticorena-Álvarez

• Department of Ophthalmology, Hospital Universitario La Princesa, Madrid, Spain

author

Guadalupe Garrido Ceca

• Department of Ophthalmology, Hospital Universitario La Princesa, Madrid, Spain

author

Diego Asensio Celdrán Vivancos

• Department of Ophthalmology, Hospital Universitario La Princesa, Madrid, Spain

References

• 1. Horatanaruang O, Chansanti O, Mitarnun W et al. Isolated corneal intraepithelial neoplasia. J Med Assoc Thai. 2005; 88(suppl 9): S134-7.
• 2. Waring GO, Roth AM, Ekins MB. Clinical and pathologic description of 17 cases of corneal intraepithelial neoplasia. Am J Ophthalmol. 1984; 97(5): 547-59.
• 3. Erie JC, Campbell RJ, Liesegang TJ. Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology. 1986; 93: 176-83.
• 4. Singh S, Mittal R, Ghosh A et al. High-Resolution Anterior Segment Optical Coherence Tomography in Intraepithelial Versus Invasive Ocular Surface Squamous Neoplasia. Cornea. 2018; 37(10): 1292-8.
• 5. Chin EK, Cortés DE, Lam A et al. Anterior segment OCT and confocal microscopy findings in atypical corneal intraepithelial neoplasia. Cornea. 2013; 32(6): 875-9.
• 6. Shields CL, Kaliki S, Kim HJ et al. Interferon for Ocular Surface Squamous Neoplasia in 81 Cases: Outcomes Based on the American Joint Committee on Cancer Classification. Cornea. 2013; 32(3): 248-56.

• Document Type: article