INVESTIGATION OF FENOFIBRATE DISSOLUTION RATE INCORPORATED ON SOLID DISPERSIONS INTO CHITOSAN

• Authors: Bożena Grimling , Maria Szcześniak , Jan Meler , Janusz Pluta
• Languages of publication: EN

Abstracts

EN

The aim of the study was to investigate the effect of chitosan on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in physical mixtures at the drug to polymer ratio of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 13 to 70 times) in fenofibrate solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of fenofibrate in the presence of chitosan at the weight ratio 1:9 increased with the increment of the molecular weight of the chitosan.
The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.

Keywords

EN

dissolution; fenofibrate; molecular weight of the chitosan; solid state

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 149-156

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, "Silesian Piast" memorial Medical University of Wroclaw

author

Maria Szcześniak

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Jan Meler

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Janusz Pluta

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

References

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• Document Type: article