THE STUDY OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF IBUPROFEN IN THE PRESENCE OF CHITOSAN

• Authors: Bożena Grimling , Jan Meler , Maria Szcześniak , Janusz Pluta , Agata Górniak
• Languages of publication: EN

Abstracts

EN

The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.

Keywords

EN

chitosan; dissolution; ibuprofen; solid dispersion

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2015
• Volume: 20
• Pages: 64-72

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland

author

Jan Meler

• Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland

author

Maria Szcześniak

• Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland

author

Janusz Pluta

• Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland

author

Agata Górniak

• Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland

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• Document Type: article