Wpływ tyreoliberyny na ośrodkową regulację układu krążenia

• Authors: Karolina Walas , Jerzy Jochem

Title variants

EN

Influence of thyroliberin on central cardiovascular regulation

• Languages of publication: PL

Abstracts

PL

Tyreoliberyna (thyrotropin releasing hormone – TRH) to tripeptyd syntetyzowany głównie w jądrze przykomorowym podwzgórza. Jest składową osi podwzgórze–przysadka–tarczyca, w której nasila procesy syntezy i wydzielania hormonu tyreotropowego. Wpływa także na uwalnianie innych hormonów (prolaktyna, wazopresyna) i neuroprzekaźników w ośrodkowym układzie nerwowym (noradrenalina i adrenalina). Działając jako neuromodulator, TRH wpływa na wiele funkcji ośrodkowego układu nerwowego. W pracy przedstawiono współzależności między układem tyreoliberynergicznym a innymi układami neuronalnymi, ze szczególnym uwzględnieniem znaczenia THR w ośrodkowej regulacji układu krążenia. Zwrócono uwagę na różnice w działaniu TRH w stanach normotensji, hipertensji oraz hipotensji.

EN

Thyroliberin (thyrotropin releasing hormone – TRH) is a tripeptide synthesized mainly in the paraventricular nucleus of the hypothalamus. It is a component of the hypothalamic–pituitary–thyroid axis, in which it intensifi es the synthesis and secretion of the thyroid stimulating hormone. It also regulates the release of other hormones (prolactin, vasopressin) and neurotransmitters in the central nervous system (noradrenaline and adrenaline). Acting as a neuromodulator, TRH aff ects many functions of the central nervous system. In the present review, we demonstrate interactions between the thyroliberinergic system and other neuronal systems, especially the role of TRH in the central cardiovascular regulation. The diff erences between TRH-induced eff ects in normotension, hypertension and hypotension have been presented.

Keywords

EN

cardiovascular system; central nervous system; ośrodkowy układ nerwowy; thyroliberin; tyreoliberyna; układ krążenia

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2012
• Volume: 66
• Issue: 5
• Pages: 87–92

Contributors

author

Karolina Walas

• Katedra i Zakład Podstawowych Nauk Medycznych Wydziału Zdrowia Publicznego Śląskiego Uniwersytetu Medycznego w Katowicach

author

Jerzy Jochem

• Katedra i Zakład Podstawowych Nauk Medycznych Wydziału Zdrowia Publicznego Śląskiego Uniwersytetu Medycznego w Katowicach ul. Piekarska 18 41-902 Bytom tel. [phone] fax [phone]

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• Document Type: article