Characteristics of ketogenic diet and its therapeutic properties in central nervous system disorders

• Authors: Arkadiusz Liśkiewicz , Halina Jędrzejowska-Szypułka , Joanna Lewin-Kowalik

Title variants

PL

Charakterystyka diety ketogennej i jej właściwości terapeutycznych w chorobach centralnego układu nerwowego

• Languages of publication: EN

Abstracts

EN

A fat-rich and low-carbohydrate ketogenic diet has been successfully used in epilepsy treatment in children and adults for many years. Lately, advances have been made in the use of ketogenics as therapy for other disorders such the tuberous sclerosis complex, brain tumors and neurodegenerative diseases: Alzheimer’s disease and Parkinson’s disease. Many studies have also shown its neuroprotective abilities. This neuroprotection is connected with the molecular mechanisms of a ketogenic diet and ketone metabolism. This review shows how a ketogenic diet induces ketosis, how it works and how the molecular mechanisms of a ketogenic diet may be used in the therapy of central nervous system disorders.

PL

Wysokotłuszczowa, niskowęglowodanowa dieta ketogenna jest terapią, która od wielu lat z sukcesem jest stosowana u dzieci i dorosłych w leczeniu epilepsji. Późniejsze badania pozwoliły na rozszerzenie poszukiwań jej terapeutycznego zastosowania o stwardnienie guzowate, guzy mózgu i schorzenia neurodegeneracyjne, jak choroba Alzheimera i choroba Parkinsona. Wiele badań wykazało również neuroprotekcyjne właściwości tej terapii. Indukowanie neuroprotekcji jest związane z molekularnymi mechanizmami działania diety ketogennej i metabolizmem ciał ketonowych. Niniejsza praca opisuje działanie diety ketogennej oraz jej mechanizmy molekularne, które mogą być wykorzystywane w terapii chorób centralnego układu nerwowego.

Keywords

EN

choroby neurodegeneracyjne; ciała ketonowe; dieta ketogenna; ketogenic diet; ketone bodies; neurodegenerative disorders; neuroprotection; neuroprotekcja

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2012
• Volume: 66
• Issue: 6
• Pages: 66–76

Contributors

author

Arkadiusz Liśkiewicz

• Department of Physiology School of Medicine in Katowice Medical University of Silesia in Katowice tel. [phone] fax [phone]

author

Halina Jędrzejowska-Szypułka

• Department of Physiology School of Medicine in Katowice Medical University of Silesia

author

Joanna Lewin-Kowalik

• Department of Physiology School of Medicine in Katowice Medical University of Silesia

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• Document Type: article