Improvement in CD4 cells counts in newly diagnosed HIV infected Cameroonian patients under HARRT is counterbalanced by the mild deleterious effects of antiretroviral therapy on liver function: a longitudinal study

• Authors: Kojom Loick Pradel , Tuileu Tchamake Sorelle Kelly , Assokom Eliane Vanessa , Kouemo Motse Francine Dorgelesse , Kamgain Mawabo Lugarde
• Languages of publication: EN

Abstracts

EN

Human immunodeficiency virus (HIV) infection still is a worldwide public health concern, but especially so in Cameroon. Still, the health of HIV-infected people has greatly improved following the introduction of highly active antiretroviral therapy (HAART). Conversely, some authors reported the occurrence of side effects. Unfortunately, data on the topic are scarce in Cameroon. This study aimed at investigating the impact of HAART on liver function in newly diagnosed HIV-infected people. An 18-month longitudinal study was carried out in a health facility in the town of Douala, Cameroon. Investigative methods relied on a questionnaire approach, clinical and biological analyses and medical records exploitation. A total of 107 patients aged 18-45 years old were included in the study. Most participants were females (94, 87.9%) and aged 30-40 years (60, 56.1%). A higher significant fraction of patients had CD4 lymphocytes counts less than 200 cells/mm3 (42, 39.3%) at baseline. We recorded a 1.5-fold increment in the CD4 lymphocytes counts over the follow up period (P-value < 0.0001). Indeed, globally, a significant increasing in ALT level was recorded over follow up. There is a critical need for paying attention to liver function in people living with HIV/AIDS and under therapy.

Keywords

EN

CD4 cells count; Douala; HAART; HIV infection; transaminases levels

Discipline

• MEDICINE: MEDICINE

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2018
• Volume: 20
• Pages: 215-225

Contributors

author

Kojom Loick Pradel

• Department of Animal Organisms, The University of Douala, Douala, Cameroon

author

Tuileu Tchamake Sorelle Kelly

• Institute for Applied Sciences, Douala, Cameroon

author

Assokom Eliane Vanessa

• Department of Biochemistry, The University of Douala, Douala, Cameroon

author

Kouemo Motse Francine Dorgelesse

• Department of Medical Laboratory Science, University of Buea, Buea, Cameroon

author

Kamgain Mawabo Lugarde

• District Hospital of Deido, Douala, Cameroon

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• Document Type: article