Cytogenetic effects in human as the result of the Chernobyl accident

• Authors: M. A. Pilinskaya
• Languages of publication: EN

Abstracts

EN

The Chernobyl accident significantly complicated the ecological situation in Ukraine. The existing environmental pollution, which was already rooted in the background, ensures for the most part that the Ukrainian population comes into contact with one of the most powerful universal mutagens - ionizing radiation. This can cause genetic damage in all living beings, including human. As such, it is essential that the Chernobyl accident victims be medically monitored using cytogenetic monitoring – the study of the frequency and spectrum of chromosome aberrations in human peripheral blood lymphocytes with the help of classical (conventional cytogenetics, G-banding analysis) and new (FISHWCP) research methods.

Keywords

EN

Chernobyl accident; cytogenetic effects; human

Discipline

• ENVIRONMENT_&_ECOLOGY: ENVIRONMENT & ECOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2015
• Volume: 1
• Pages: 18-22

Contributors

author

M. A. Pilinskaya

• Research Centre for Radiation Medicine, Academy of Medical Sciences of Ukraine, Kiev, Ukraine

References

• [1] Bochkov N. P., State-of-the-art review of cytogenetic researches after Chernobyl accident. The Bulletin of the Russian Academy of medical sciences. Мedicine. 1993, № 6, pp. 51-56.
• [2] Maznik N. A. Cytogenetic effects serving as the biological indicator of radiation of liquidators of consequences of Chernobyl accident. Ukr. Radiol., 1999, № 3, pp. 337-338.
• [3] Sevankaev A. V. Some results of cytogenetic researches in connection with an estimation of consequences of Chernobyl accident. Radiation biology. Radioecology. V. 40, № 5. 2000, pp. 589-596.
• [4] Pilinskaja M. A., Shemetun A. M., Dybski S. S., Dybskaya E. B., et al., Results of 14year cytogenetic monitoring of the priority observation groups victims of the impact of factors of the accident at the Chernobyl atomic power station. The Bulletin of the Russian Academy of medical sciences., Medicine 2001, № 10, pp. 80-84.
• [5] Maznyk N. О., Cytogenetic effects as a biological indicator of low doses of ionizing radiation health effects in the early and later periods after radiation exposure in persons of Chornobyl contingent: Thesis Autoabstract of Doctor of Biological Sciences. Kyiv, 2005. 46 p.
• [6] Pedan L.R., Pilins’ka М.А. Evaluation of stability of peripheral blood lymphoid cell chromosomes in the persons suffered from influence of Chornobyl accident with the help of testing mutagenic pressure in vitro // Reports of National Academy of Sciences of Ukraine. 2004, № 12, pp. 175-179.
• [7] Pilinska М. А., Dybsky S. S., Dybska О. B., Pedan L. R. Revealing chromosome irregularity in offspring of parents radiation-exposed due to Chornobyl disaster with the help of long-term lymphoid cells cultivation in a peripheral blood // Cytology and Genetics. 2005, V. 39, № 4, p. 3240.
• [8] Dubrova, Yuri E; Nesterov, Valeri N; Krouchinsky, Nicolay G; Ostapenko, Vladislav A; et al., Human minisatellite mutation rate after the Chernobyl accident. Nature, Apr 25, 1996, 380, 6576
• [9] M Santoro, G A Thomas, G Vecchio, G H Williams, A Fusco, G Chiappetta, V Pozcharskaya, T I Bogdanova, E P Demidchik, E D Cherstvoy, L Voscoboinik, N D Tronko, A Carss, H Bunnell, M Tonnachera, J Parma, J E Dumont, G Keller, H Höfler and E D Williams. Gene rearrangement and Chernobyl related thyroid cancers. British Journal of Cancer (2000) 82, 315–322. doi:10.1054/bjoc.1999.0921
• [10] Likhtarev IA, Sobolev BG, Kairo IA, Tronko ND, Bogdanova T, Oliynyk V, et al. Thyroid cancer in the Ukraine. Nature 1995; 375: 365.
• [11] Kazakov V, Demidchik E, Astakhova L. Thyroid cancer after Chernobyl. Nature 1992; 359: 21–3
• [12] Baverstock K, Egloff B, Pinchero A, Ruchti C, Williams D. Thyroid cancer after Chernobyl. Nature 1992; 359: 21–2.
• [13] Furmanchuk AW, Averkin JI, Egloff B, Ruchti C, Abelin T, Schappi W, et al. Pathomorphological findings in thyroid cancer of children from the Republic of Belarus. Histopatology 1992; 21: 401–8.
• [14] Nikiforov Y, Gnepp DR. Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991–1992) from the Republic of Belarus. Cancer 1994; 74: 748–66.
• [15] Harach HR, Williams ED. Childhood thyroid cancer in England and Wales. Br J Cancer 1994; 72: 777–83.
• [16] Bogdanova T, Bragarnik MM, Tronko ND, Harach HR, Thomas GA, Williams ED. Childhood thyroid cancer after Chernobyl. J Endocrinol 1995; 144(Suppl OC): 25.

• Document Type: article