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2022 | 42 | 123-138

Article title

Tramadol and its health implications

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EN

Abstracts

EN
Tramadol is classified as a pain reliever having analgesic properties. Pain is an unpleasant sensation that occurs most commonly as a result of tissue injury. Most opioid medicines are classed as alkaloid compounds and are classified as narcotics because they work on the central nervous system (CNS) to treat pain in conditions such as osteoarthritis, cancer, tooth pain, and kidney discomfort. Tramadol is plentiful in the roots of Nauclea latofolia. It can be chemically and biosynthetically produced from cyclohexanone and L-phenylalanine, respectively. The tramadol dose determines the toxicity stage. The medicine can be detoxified in the liver using monooxygenase enzymes and conjugating agents if taken in excess of the recommended dose. Tramadol works on the central nervous system by acting as a vulnerable agonist and inhibiting serotonin re-uptake. Seizures, genitourinary, dermatologic, and respiratory depression are just a few of tramadol's many side effects. The focus of this research will be on tramadol and its health consequences.

Keywords

EN

Year

Volume

42

Pages

123-138

Physical description

Contributors

  • Department of Biochemistry, Faculty of Life Science, Federal University of Technology Minna, Bosso LGA, Niger State, Nigeria
  • Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
author
  • Department of Biochemistry, Faculty of Life Science, Federal University of Technology Minna, Bosso LGA, Niger State, Nigeria

References

  • [1] Kidd, B.L., Langford, R.M. and Wodehouse, T. (2007). Arthritis and pain. Current approaches in the treatment of arthritic pain. Arthritis Resources Journal, 9: 1-7
  • [2] Dayer, P., Desmeules, J. and Collart, L. (2007). Pharmacology of tramadol. Drugs, 53(2): 18-24.
  • [3] Bravo, L., Mico, J.A . and Berrocoso, E. (2007). Discovery and development of tramadol for the treatment of pain. Expert Opinion on Drug Discovery, 12: 1281-1291
  • [4] Martínez, M.A., Ballesteros, S., Almarza, E. and Garijo, J. (2016). Death in a legal poppy field in Spain. Forensic Science International, 265: 34-40
  • [5] Karbakhsh, M. and Salehian, Z.N. (2007). Acute opiate overdose in Tehran: the forgotten role of opium. Addiction Behavior, 32: 1835-1842
  • [6] Zaaijer, E.R., Bruijel, J., Blanken, P., Hendriks, V., Koeter, M.W .J. and Kreek, M.J. (2014). Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence. Drug Alcohol Depend, 145: 101-105
  • [7] Threlkeld, M., Parran, T., Adelman, C. and Grey, S. (2006). Tramadol versus buprenorphine for the management of acute heroin withdrawal: a retrospective cohort controlled study. American Journal of Addiction, 15: 186-191
  • [8] World Health Organization, (2013). WHO’s Pain Ladder for Adults, World Health Organization, Geneva, 2014 Accessed September 17, 2013 (Available from:) http://www.who.int/cancer/palliative/painladder/en/
  • [9] Kenzie, L.P., Donald, R.J. and Margaret, T. (2001). Abuse potential and pharmacological comparison of tramadol and morphine. Drug Alcohol Depend, 27: 7-17
  • [10] Hennies, H.H., Friderichs, E. and Schneider, J. (2008). Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Journal of Drug Resources, 38: 877-880
  • [11] Kusari, S., Tatsimo, J., Zühlke, S., Talontsi, F.M., Kouam, S.F. and Spiteller, M. (2014). Tramadol a true natural product. Chemical International Edition, 53: 12059-12272
  • [12] Boumendjel, A., Taiwe, G.S., Bum, E.N., Chabrol, T., Beney, C., Sinniger, V., Haudecoeur,R., Marcourt, L., Challal, S., Queiroz, E.F., Souard, F. and Waard, M.D. (2013). Occurrence of the synthetic analgesic tramadol in an african medicinal plant. Chemical International Edition, 52: 11780-11784
  • [13] Lecerf-Schmidt, F., Haudecoeur, R., Peres, B., Queiroz, F.M.M., Marcourt, L., Challal, S.,Queiroz E.F., Taiwe, G.S. and Boumendjel, A. (2015). Biomimetic synthesis of tramadol. Chemical Community (Cambridge, U.K.), 51: 14451-14453
  • [14] Grond, S., Meuser, T., Zech, D., Hennig, U. and Lehmann, K.A. (2005). Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient-controlled analgesia. Pain, 62(3): 313-320
  • [15] Raffa, R.B., Buschmann, H., Christoph, T., Eichenbaum, G., Englberger, W ., Flores, C.M., Hertrampf, T., Kögel, B., Schiene, K., Straßburger, W., Terlinden, R. and Tzschentke, T.M. (2012). Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opinion in Pharmacothermal, 13(10): 1437-1449
  • [16] Poupon, E. and Nay, B. (2011). Biomimetic Organic Synthesis, first edition, Wiley-VCH Verlag GmbH&Co, Weinheim, Germany, 2011
  • [17] Burke, D. and Henderson, D.J. (2002). Chirality: a blueprint for the future. British Journal of Anaesthesia, 88(4): 563-576
  • [18] Canepa, G., Di-Somma, C., Ghia, M., Vadala, A., Real, M., Cerruti, S., Stasi, M. and Trezzi, P. (2003). Post-operative analgesia with tramadol. International Journal of Clinical Pharmacology Resources, 13: 43-51
  • [19] Malik, A., Kaul, R. and Kaul, V. (2015). Clinical effectiveness of three analgesic formulations on post- operative endodontic pain: a Pilot study. International Journal of Therapy Application, 25: 7-11
  • [20] Sunshine, A. (2004). New clinical experience with tramadol. Drugs, 47: 8-18
  • [21] Yilmaz, M.Z., Torun, C., Sarihasan, B.B., Kelsaka, E., Koksal, E., Tas, N. and Kuruoglu, E. (2015). Comparison of the analgesic effects of paracetamol and tramadol in lumbardisc surgery. Turkish Journal of Medical Science, 45: 438–442
  • [22] Hussein, O.A., Adel, I.M . and Kadhim, A.A. (2015). Efficacy of combined tramadol with diclofenac in comparison with monotherapy treatment using Buscopan Diclofenac or tramadol in renal pain control. Medical Journal of Baby, 12: 1070–1074
  • [23] Bloor, M., Paech, M.J. and Kaye, R. (2012). Tramadol in pregnancy and lactation. International Journal of Obstetric Anesthesia, 2: 163–167
  • [24] James, M.F.M., Heijke, S.A.M., and Gordon, P.C. (2006). Intravenous tramadol versus epidural morphine for post-thoracotomy pain relief: a placebo- controlled double-blindtrial. Anesthetic and Analgesic, 83: 87-91
  • [25] Lomona, J. (2005). Is tramadol a suitable analgesic for high risk patients after heart surgery? Britain Journal of Anaesthetic, 74(2): 7
  • [26] Kupers, R., Callebaut, V., Debois, V., Camu, F., Verbogh, C., Coppejars, H. and Adriansen, H. (2005). Efficacy and safety of oral tramadol and pentazocine for post-operative pain following prolapsed intervertebral disc repair. Anaesthesiology in Belgium, 46: 31-37
  • [27] Hopkins, D., Shipton, E.A. and Potgieter, D. (2008). The comparison of tramadol and morphine by subcutaneous PCA. Canadian Journal of Anaesthetic, 45: 435-442
  • [28] Rud, V., and Fischer, M.V. (2004). Postoperative analgesia with tramadol: continuous in fusion versus repetitive bolus administration. Anaesthetist, 43: 316-321
  • [29] Barsoum, M.W . (2005). Comparison of the efficacy and tolerability of tramadol, pethidine, and nalbuphine in children with postoperative pain. Clinical Drug Investment, 9: 183-190
  • [30] Bosenberg, A. and Ratcliffe, S. (2008). The respiratory effects of tramadol in child renunder halothanean aesthesia. Anaesthesia, 53: 960-964
  • [31] McQuay, H.J. and Moore, R.A. (2008). Postoperative analgesia and vomiting, with special reference today-case surgery: a systematic review. Health Technology Assessment, 2: 1-236
  • [32] Lehmann, K.A. (2007). Tramadol in acute pain. Drugs, 53(2): 25-33
  • [33] Bamigbade, T.A. and Langford, R.M. (2008). The clinical use of tramadol hydrochloride. Pain Reviews, 5: 155-182
  • [34] Duthie, D.J.R. (2008). Remifentanil and tramadol. Britain Journal of Anaesthetic, 81: 51-57
  • [35] Vickers, M.D. and Paravicini, D. (2005). Comparison of tramadol with morphine for post-operative pain following abdominal surgery. European Journal of Anaesthesiology, 12: 265-271
  • [36] W ilder-Smith, C.H., Hill, L., Osler, W . and O‘Keefe, S. (2009). Effect of tramadol andmorphine on pain and gastrointestinal motor function in patients with chronic pancreatitis. Digestive Disease Science, 44: 1107-1116
  • [37] De-Witte, J., Deloof, T., de-Veylder, J. and Housemans, P.R. (2007). Tramadol in the treatment of post-anaesthetic shivering. Anaesthesiology, 41: 506-510
  • [38] Chan, A.M., Ng, K.F., Tong, E.W. and Jan, G.S. (2009). Control of shivering under regional anesthesia in obstetric patients with tramadol. Canadian Journal of Anaesthetic, 46: 253-258
  • [39] Budd, K. and Langford, R. (2009). Tramadol revisited. Britain Journal of Anaesthetic, 82: 493-495
  • [40] Mackin, G.A. (2007). Medical and pharmacologic management of upper extremity neuropathic pain syndromes. Journal of Hand Resources, 10: 96-109
  • [41] Harati, Y., Gooch, C. and Swenson, M. (2008). Double-blind randomised trial of tramadol for the treatment of the pain of diabetic peripheral neuropathy. Neurology, 50: 1842-1846
  • [42] Roth, S. (2008). Efficacy and safety of tramadol hydrochloride in breakthrough musculoskeletal pain attributed to osteoarthritis. Journal of Rheumatology, 25: 45-54
  • [43] Biasi, G., Manca, S., Manganelli, S. and Marcolongo, R. (2008). Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo. International Journal of Clinical Pharmacology Resources, 18: 13-19
  • [44] Nossol, S. (2008). Treatment of pain with sustained-release tramadol. International Journal of Clinical Practise, 52: 94-126
  • [45] Sorge, J. and Stadler, T. (2007). Comparison of the analgesic efficacy and tolerability of tramadol 100 mg sustained-release tablets and tramadol 50 mg capsules for the treatment of chronic lowback pain. Clinical Drug Investment, 14: 157-164
  • [46] Schnitzer, T.J. (2008). Non-NSAID pharmacologic treatment options for the management of chronic pain. American Journal of Medicine, 195(1): 45-52
  • [47] Dalgin, P.H. (2005). Use of tramadol in chronic pain. Clinical Geriatrics, 3: 1-6
  • [48] Abel, S.R. (2005). Tramadol: an alternative analgesic to traditional opioids and NSAIDs. Journal of Pharmaceutical Care and Pain Symptom Control, 3(1): 5-29
  • [49] Tegeder, I., Lötsch, J. and Geisslinger, G. (2002). Pharmacokinetics of opioids in liver disease. Clinical Pharmacokinetic, 37: 17-40
  • [50] Lintz, W., Barth, H. and Osterloh, G. (2008). Pharmacokinetics of tramadol and bioavailability of enteraltramadol formulations. 3rd communication: suppositories. Clinical Pharmacy, 48: 889-899
  • [51] Lee, C.R., McTavish, D. and Sorkin, E.M. (2003). Tramadol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46: 313-340
  • [52] Liao, S., Hills, J. and Stubbs, R.J. (2002). The effect of food on the bioavailablity of tramadol. Pharmaceutical Resources, 9: 308
  • [53] Gaynes, B.I. and Barkin, R.I. (2009). Analgesics in ophthalmic practice: a review of theoral non-narcoticagent tramadol. Visual Science, 76: 455-461
  • [54] De Jong, R.H. (2007). Comment on the hypoalgesic effect of tramadol in relation to CYP2D6 [comment]. Pain Digestion, 7(4): 245
  • [55] Paar, W.D ., Poche, S. and Gerloff, J. (2007). Polymorphic CYP2D 6 mediates O-demethylation of the opioid analgesic tramadol. European Journal of Clinical Pharmacology, 53: 235-239
  • [56] Barkin, R.L. (2005). Focus on tramadol: a centrally acting analgesic for moderate to moderately severe pain. Formulary, 30: 321-325
  • [57] Minami, K., Uezono, Y. and Ueta, Y. (2007). Pharmacological aspects of the effects of tramadol on G-protein coupled receptors. Journal of Pharmacological Science, 103: 253-260
  • [58] Scott, L.J. and Perry, C.M. (2000). Tramadol: a review of its use in perioperative pain. Drugs, 60(1): 139-176
  • [59] Langley, P.C., Patkar, A.D., Boswell, K.A., Benson, C.J. and Schein, J.R. (2010). Adverseevent profile of tramadol in recent clinical studies of chronic osteoarthritis pain. Current Medical Research and Opinion, 26(1): 239-251
  • [60] Keating, G.M. (2006). Tramadol sustained-release capsules. Drugs, 66(2): 223-230
  • [61] Spiller, H.A., Gorman, S.E. and Villalobos, D. (2007). Prospective multicenter evaluation of tramadol exposure. Journal of Toxicology and Clinical Toxicology, 35: 361-364
  • [62] Houmes, R.M., Voets, M.A. and Verkaaik, A. (2002). Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain with special regard to respiratory depression. Anesthetic and Analgesic, 74: 510-514
  • [63] Langford, R.M., Bakhshi, K.N. and Moylan, S. (2008). Hypoxaemia after lower abdominal surgery: comparison of tramadol and morphine. International Journal of Acute Pain Management, 1: 7-12
  • [64] Tarkkila, P., Tuominen, M. and Lindgren, L. (2008). Comparison of respiratory effects of tramadol and pethidine. European Journal of Anaesthesiology, 15: 64-68
  • [65] Marechal, C., Honorat, R. and Claudet, I. (2011). Serotonin syndrome induced by tramadol intoxication in an 8-month-old infant. Pediatric Neurology, 44: 72-74
  • [66] Jeppesen, U. Gram, L.F. and Vistisen, K. (2006). Dose- dependent inhibition of CYP1A 2, CYP2C19, and CYP2D 6 by citalopram, fluoxetine, fluvoxamine and paroxetine. European Journal Pharmacology, 51: 73-78
  • [67] Frank, C. (2008). Recognition and treatment of serotonin syndrome. Canadian Family Physiology, 54: 988-992
  • [68] Barsotti, C.E., Mycyk, M.B. and Reyes, J. (2003). Withdrawal syndrome from tramadol hydrochloride. American Journal of Emergency Medicine, 21: 87-88
  • [69] Kahn, L.H., Alderfer, R.J. and Graham, D.J. (2007). Seizures reported with tramadol. Journal of American Medicine and Anatomy, 278: 1661
  • [70] Vogel, W ., Burchardi, H., Sihler, K. and Valic, L. (2008). The respiratory and circulatory effects of tramadol. Drug Resources, 28: 183-186
  • [71] Afshari, R. and Ghooshkhanehee, H. (2009). Tramadol overdose induced seizure, dramatic rise of CPK and acute renal failure. Journal of Pakistan Medicine Association, 59: 178
  • [72] Bekjarovski, N., Chaparoska, D. and Radulovikj-Bekjarovska, S. (2012). Seizures after use and abuse of tramadol. Prilozi, 33: 313-318

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article

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bwmeta1.element.psjd-78de2db9-61d8-4c4f-ae6b-52ce792356f2
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