FRUCTOSE AFFECTS FATTY ACIDS PROFILE IN LIVER CELLS IN VITRO AND IN VIVO MODELS IN RATS

• Authors: Malgorzata TYSZKA- CZOCHARA , Joanna GDULA- ARGASIŃSKA , Paweł PAŚKO , Tadeusz LIBROWSKI , Magdalena GAWEŁ , Magdalena OLBERT , Anna LIPKOWSKA
• Languages of publication: EN

Abstracts

EN

It was reported that dietary fructose imposes a number of effects on lipid metabolism including hypertriglyceridemia. The daily intake of fructose in humans is mainly due to sucrose. It was reported that the consumption is still increasing, making a background for health implications. The mechanism of metabolic disorders is poorly understood, but a lot of studies indicate that the liver lipid homeostasis deregulation is essential for a fructose effect on metabolism. The aim of the study is to estimate if fructose affects the profile of fatty acids in in vitro and in vivo models. In this study in vitro and in vivo experiments were conducted to assess the effect of dietary fructose on the fatty acid profile in the cell culture or in the liver of rats. The results showed that in the fructose experimental groups, both in the cell and liver homogenates, the content of the saturated fatty acids were significantly higher than in control groups. According to the obtained data fructose in the medium and in the diet affects saturation of fatty acids in the cell cultures and in the livers of rats. The findings obtained in the experiments support the thesis that fructose influences the homeostasis of lipid metabolism in the liver and may give an opportunity to discuss the limitation of the content of this kind of sugar in food.

Keywords

EN

Diet; Fatty acids profile; Fructose; Hep G2 cell culture; Lipid metabolism

Discipline

• MEDICAL_BIOLOGY: MEDICAL BIOLOGY

• Publisher: ZOZ Ośrodek UMEA SHINODA-KURACEJO
• Journal: Medicina Internacia Revuo
• Year: 2014
• Volume: 26
• Issue: 102
• Pages: 42- 46

Contributors

author

Malgorzata TYSZKA- CZOCHARA

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Joanna GDULA- ARGASIŃSKA

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Paweł PAŚKO

• Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Tadeusz LIBROWSKI

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Magdalena GAWEŁ

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Magdalena OLBERT

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

author

Anna LIPKOWSKA

• Department of Radioligands, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

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• Document Type: article