THE INVESTIGATION OF PHYSICOCHEMICAL PROPERTIES OF THE SOLID DISPERSIONS IN THE PRESENCE POLYMERIC CARRIER- CHITOSAN

• Authors: Bożena Grimling , Jan Meler , Janusz Pluta , Agata Górniak
• Languages of publication: EN

Abstracts

EN

The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.

Keywords

EN

DSC; IR studies; chitosan; fenofibrate; physical mixtures; saturation solubility; solid dispersions

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 167-173

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, "Silesian Piast" memorial Medical University of Wroclaw

author

Jan Meler

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Janusz Pluta

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Agata Górniak

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

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• Document Type: article