The circulatory levels of Serotonin and Dopamine and physical fitness factors in active and inactive men addicted to opium during rehabilitation

• Authors: Hamid Arazi , Rahim Mollazadeh , Seyedeh Shiva Dadvand , Maryam Davaran
• Languages of publication: EN

Abstracts

EN

Addiction to drugs is one of the significant problems in many countries. Opium is a kind of drug that its use goes back to many years ago. Dopamine and serotonin are neurotransmitters involved in the process of addiction. As a result, this study aimed to investigate the blood levels of serotonin, dopamine and physical fitness factors in active and inactive men addicted to opium during their rehabilitation period. This study is a descriptive and Causal after the occurrence. A total of 34 men addicted to opium referring to rehabilitation center had been admitted voluntarily as samples were available in the study. According to a questionnaire answered by them, 16 of them did exercise during their rehabilitation period (active group) and 18 of them did not do any physical activity during this period (inactive group). 5 cc of peripheral blood samples were obtained from both groups and were tested their aerobic capacity, muscular endurance, flexibility, body composition, blood pressure and heart rate. Statistical analysis showed that blood levels of serotonin and dopamine in active group were significantly more than inactive group (p<0.05). In addition, the active group compared with the inactive group had low body fat percent, more muscular endurance, more flexibility, and low resting heart rate (p<0.05). According to the findings, we can conclude that low physical activity but as regular walking can affect blood levels of serotonin and dopamine, and health-related fitness factors of addicted men and as a non-drug treatment is helpful.

Keywords

EN

Addiction; Dopamine; Exercise; Opium; Serotonin

• Publisher: Institute of Physical Education and Tourism. Jan Długosz University of Czestochowa
• Journal: Physical Activity Review
• Year: 2016
• Volume: 4
• Pages: 1-8

Contributors

author

Hamid Arazi

• Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.

author

Rahim Mollazadeh

• Department of Psychology, Faculty of Humanities Sciences, University of Guilan, Rasht, Iran.

author

Seyedeh Shiva Dadvand

• Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.

author

Maryam Davaran

• Department of Physical Education, Islamic Azad University, Rasht Branch, Rasht, Iran.

References

• 1. Reed E, Amaro H, Matsumoto A, Kaysen D: The relation between interpersonal violence and substance use among a sample of university students: Examination of the role of victim and perpetrator substance use. Addictive Behaviors, 2009; 34(3): 316-318.
• 2. Karam GA, Reisi M, Kaseb AA, Khaksari M, Mohammadi A, Mahmoodi M: Effects of opium addiction on some serum factors in addicts with non-insulin-dependent diabetes mellitus. Addiction Biology, 2004; 9(1): 53-58.
• 3. Le Moal, M, Koob GF: Drug addiction: pathways to the disease and pathophysiological perspectives. European Neuropsychopharmacology, 2007; 17(6): 377-393.
• 4. Hicks RR, Boggs A, Leider D, Kraemer P, Brown R, ScheffS W, Seroogy KB: Effects of exercise following lateral fluid percussion brain injury in rats. Restorative Neurology and Neuroscience, 1998; 12(1): 41-48.
• 5. Floresco SB, Blaha CD, Yang CR, Phillips AG: Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection. The Journal of Neuroscience, 2001; 21(8): 2851-2860.
• 6. Sadock BJ, Sadock VA, Levin ZE: Kaplan and Sadock's Study Guide and Self-Examination Review in Psychiatry. Lippincott Williams & Wilkins, 2007; 468.
• 7. Gold M: The neurobiology of addictive disorders, bore miller the principal and practice of addictions psychiatry. Philadelphi WB Saunders, 1997; 57-69.
• 8. Micheal S: Changing brain chemistry with intense exercise for drug addiction prevention and recovery. Research Confronts Reality, 2002; 1: 716-51.
• 9. Ehringer MA, Hoft NR, Zunhammer M: Reduced alcohol consumption in mice with access to a running wheel. Alcohol, 2009; 43(6): 443-452.
• 10.Alex F: Assessment of body anthropomtric. In: Timoth G, Reynaldo M. Anthropometric standardization referencemanual. 2nded. New York: Human Kinetics Press. 1988; 423-516.
• 11.George JD, Vehrs PR, Allsen, PE, Fellingham GW, Fisher AG: VO2max estimation from a submaximal 1-mile track jog for fit college-age individuals. Medicine and Science in Sports and Exercise, 1993; 25(3): 401-406.
• 12.Cosgrove KP, Hunter RG, Carroll ME: Wheel-running attenuates intravenous cocaine selfadministration in rats: sex differences. Pharmacology Biochemistry and Behavior, 2002; 73(3): 663- 671.
• 13.O'dell SJ, Galvez BA, Ball AJ, Marshall JF: Running wheel exercise ameliorates methamphetamine-induced damage to dopamine and serotonin terminals. Synapse 2012. 66(1): 71-80.
• 14.McGovern MK: The Effects of Exercise on the Brain. Biology 202, second web papers on serendip. 2005.
• 15.Alaei H, Esmaeili M, Nasimi A, Pourshanazari A: Ascorbic acid decreases morphine selfadministration and withdrawal symptoms in rats. Pathophysiology, 2005; 12(2): 103-107.
• 16.MacRae PG, Spirduso WW, Cartee GD, Farrar RP, Wilcox RE: Endurance training effects on striatal D 2 dopamine receptor binding and striatal dopamine metabolite levels. Neuroscience letters, 1987; 79(1): 138-144.
• 17.Vučcković MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, Petzinger GM. Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [18F] fallypride. Movement Disorders, 2010; 25(16): 2777-2784.
• 18.Chaouloff F, Laud, D, Meringo D: Amphetamine and alpha- methyl p- tyrosine affect the exercise induced imbalance between the availability of tryptrophan and senthesis of serotonin in the brain of the rat. Neuropharmacology, 1986; 26(8): 1099 – 1106.
• 19. Langfort J, Barańczuk E, Pawlak D, Chalimoniuk M, Lukačova N, Maršala J, Górski J: The effect of endurance training on regional serotonin metabolism in the brain during early stage of detraining period in the female rat. Cellular and Molecular Neurobiology, 2006; 26(7-8): 1325- 1340.
• 20.Dey S, singh R, Dey P: Exercise training: signification of regional altrrations in serotonin metabolism of rat brain in relation antidepressant effect of exercise. Physiology and Behavior, 1992; 52: 1095- 10099.
• 21. Pescatello LS: Exercise and hypertension: recent advances in exercise prescription. Current hypertension reports, 2005; 7(4): 281-286.
• 22. Swain DP, Franklin BA: Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. The American Journal of Cardiology, 2006; 97(1): 141-147.
• 23. Williams, P. T: Relationships of heart disease risk factors to exercise quantity and intensity. Archives of Internal Medicine, 1998; 158(3), 237-245.
• 24. Bassuk SS, Manson JE: Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. Journal of Applied Physiology, 2005; 99(3): 1193- 1204.
• 25. Parizkova J: Total body fat and skin folds thickness in children. Metabolism, 1961; 10:794-801.
• 26. Wimberly MG, Manore MM, Woolf K, Swan PD, Carroll SS: Effects of habitual physical activity on the resting metabolic rates and body composition of women aged 35 to 50 years. Journal of American Diet, 2001; 101(10): 36-41.
• 27. Skinner JS: Physiological response of men to l, 3 and 5 day per week training programs. Journal of Research in Sport, 2005; 57(2): 62-75.
• 28.Kohrt WM, Obert KA, Holloszy JO: Exercise training improves fat distribution patterns in 60- to70-year-old men and women. Journal of Gerontology, 1992; 47(4): 99-105.
• 29.Dolezal BA, Chudzynski J, Storer TW, Abrazado M, Penate J, Mooney L, Cooper C.B: Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment. Journal of Addiction Medicine, 2013; 7(2): 8-122.
• 30.Aagaard P, Andersen JL: Effects of strength training on endurance capacity in top‐level endurance athletes. Scandinavian Journal of Medicine & Science in Sports, 2010; 20(2): 39-47.
• 31. Tanaka H, Swensen T: Impact of resistance training on endurance performance. Sports Medicine, 1998; 25(3): 191-200.
• 32.Macek M, Bell DI, Rutenfranz J, Vavra J, Musopust J, Neidhart B, Schmidt KH: A corparison of coronary risk factors in groups of trained and untrained adolescents. European Journal of Applied Physiology and Occupational Physiology (Berlin, FRG), 1998; 58(6): 5-577.
• 33. Shahana A, Nair US, Hasrani SS: Effect of aerobic exercise program on health related physical fitness components of middle aged women. British Journal of Sports Medicine, 2010; 44(1): 19-29.

• Document Type: paper