INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.

Keywords

EN

anti-inflammatory drugs; esophageal infections.; esophageal mucosa; gastro-esophageal reflux; hydrophilic gels; physiological environment of gastro-esophageal

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2019
• Volume: 24
• Pages: 135 - 144

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy The “Silesian Piasts” memorial Wroclaw Medical University

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• Document Type: article