A comparison of a single genetic factor, two stress factors, and one psychosocial coping factor as predictors of depression in an Australian community sample

• Authors: Christopher F. Sharpley , Suresh K. A. Palanisamy , Kate Metcalf , Kim A. Jones , Brian Kelly , James R. McFarlane
• Languages of publication: EN

Abstracts

EN

Aim. Although both have shown significant effects upon depression in clinical samples, no direct comparison has been reported of the relative power of psychological resilience and the short form of the serotonin transporter gene 5-HTTLPR as predictors of depression in a community sample. material and methods. In a sample set by a priori power analysis, 67 adult females and 59 adult males were used to enable a comparison between a single genetic factor, childhood stressors, recent stressors, psychological resilience and depression. Results. None of genotype, childhood or recent stressors was significantly associated with depression scores, but resilience was a significant inverse predictor of depression scores and also of the presence of clinically significant depression. discussion. These data suggest that measures of an individual's ability to resist or recover from stress may be useful in assessing vulnerability to depression when used with 'at risk' individuals in everyday practice.

Keywords

EN

depression; distal; genes; proximal; resilience; stressors

Discipline

• MEDICINE: MEDICINE

• Publisher: Polish Psychiatric Association Editorial Committee
• Journal: Archives of Psychiatry and Psychotherapy
• Year: 2014
• Volume: 16
• Issue: 4
• Pages: 15–26

Dates

published

2014

Contributors

author

Christopher F. Sharpley

author

Suresh K. A. Palanisamy

author

Kate Metcalf

author

Kim A. Jones

author

Brian Kelly

author

James R. McFarlane

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• Document Type: article