Aktualne i nowe strategie leczenia aktywnej orbitopatii tarczycowej

• Authors: Joanna Wierzbowska

Title variants

EN

Current and novel strategies for the treatment for active thyroid orbitopathy

• Languages of publication: PL

Abstracts

PL

Orbitopatia tarczycowa, zwana także oftalmopatią Gravesa, jest następstwem reakcji autoimmunologicznej w oczodole wywołanej przez wspólny dla tarczycy i oczodołu antygen lub antygeny. W niniejszym artykule na podstawie koncepcji patogenezy orbitopatii tarczycowej omówiono aktualną strategię oraz nowe kierunki leczenia zarówno hipertyreozy, jak i aktywnej fazy oftalmopatii. Tradycyjna strategia leczenia orbitopatii obejmuje leczenie immunosupresyjne za pomocą glikokortykosteroidów, radioterapię oczodołów i dekompresję chirurgiczną. Nowe kierunki terapii związane są z zastosowaniem leków specyficznie modulujących określone białka komórkowe zaangażowane w szlaki reakcji autoimmunologicznej w oczodole. Należą do nich przeciwciała monoklonalne, inhibitory cytokin oraz selektywne związki immunosupresyjne.

EN

Graves’ ophthalmopathy is a consequence of an autoimmune orbital reaction that is caused by an antigen or antigens that are common to the thyroid and orbit. This review discusses the pathogenesis of thyroid orbitopathy, current treatment strategies, and new treatment options for both hyperthyroidism and the active phase of ophthalmopathy. The traditional strategy for treating Graves’ ophtalmopathy involves immunosuppressive therapy with steroids, orbital radiation therapy, and surgical decompression. New treatment options include the use of drugs that modulate specific cellular proteins that are involved in orbital autoimmune pathways. These include monoclonal antibodies, cytokine inhibitors, and selective immunosuppressants.

Keywords

EN

Graves' ophthalmopathy; autoimmunity; glicocorticosteroids; hyperthyroidism; immunosuppression; monoclonal antibodies; radiotherapy

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OphthaTherapy
• Year: 2020
• Volume: 7
• Issue: 2
• Pages: 108-115

Contributors

author

Joanna Wierzbowska

• Klinika Okulistyki CSK MON, Wojskowy Instytut Medyczny w Warszawie

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• Document Type: article