Efficacy and safety of non-pegylated liposomal doxorubicin in metastatic breast cancer therapy

• Authors: Elżbieta Wójcik , Joanna Kufel-Grabowska , Joanna Gierba-Tomczyk
• Languages of publication: EN

Abstracts

EN

Breast cancer is the most frequently diagnosed female cancer in Poland (over 17,500 women). Anthracyclines have become one of the most important drugs in breast cancer systemic treatment. In the treatment of metastatic disease combination chemotherapy with doxorubicin provides the objective response rate of 60–85%, and the median time of progression-free survival is about 12 months. Non-pegylated liposomal doxorubicin (NPLD) in combination with cyclophosphamide is associated with a lower risk of cardiotoxicity, higher efficacy and more favourable toxicity profile as compared with conventional anthracycline regimes. Two cases of females patients treated with NPLD described in this article demonstrate the importance of the choice of chemotherapy, professional monitoring, early detection and treatment of adverse effects. Non-pegylated liposomal doxorubicin ordained in systemic treatment of stage IV breast cancer prolongs survival and enhances the quality of life. It is a reasonable option for palliative therapy.

Keywords

EN

breast cancer; non-pegylated liposomal doxorubicin; treatment

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2017
• Volume: 7
• Issue: 4
• Pages: 162-167

Contributors

author

Elżbieta Wójcik

• Department of Clinical Oncology and Chemotherapy, HCP Medical Centre, St. John Paul II Hospital in Poznan

author

Joanna Kufel-Grabowska

• Greater Poland Centre of Oncology in Poznan

author

Joanna Gierba-Tomczyk

• Department of Clinical Oncology and Chemotherapy, HCP Medical Centre, St. John Paul II Hospital in Poznan

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• Document Type: article