Currently most of the scientific journals accept to publish only ”positive effects” of experimental and clinical research. Only successful studies have the right to be published and cited. However, positive effects in research are frequently achieved after years of negative results. The negative results should also be accessible for scientific community as they represent the main source of progress, of inspiration, and of hope. This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.