Inflammatory response to a marathon run in amateur athletes

• Authors: Anna Maria Kaleta-Duss , Zuzanna Lewicka-Potocka , Alicja Dąbrowska-Kugacka , Grzegorz Raczak , Anna Siekierzycka , Marcin Woźniak , Leszek Kalinowski , Ewa Katarzyna Lewicka

Abstracts

EN

Background: While moderate physical exercise has positive effects on the cardiovascular system, the data regarding intensive endurance sports is biased with studies suggesting that the inflammatory response to strenuous exercise may act proarrhythmogenic. In amateurs, the effects of intensive endurance exercise on the cardiovascular system have not been studied. Analysis of the effects of a marathon on the kinetics of inflammatory biomarkers may bring new insights into this issue. Material and methods: We studied the effect of a marathon on the kinetics of inflammatory biomarkers: Endothelin-1 (ET-1), Pentraxin-3 (PTX-3), Neopterin and Interleukin-6 (IL-6) in the population of 35 amateur male marathoners. The study was divided into 3 stages: two weeks prior to the marathon (S1), at the finish line (S2) and two weeks after (S3). Blood analyses for biomarkers were performed at each stage. Results: The concentrations of ET-1 (3.20 ± 0.90 vs. 1.30 ±0.34 pg/ml, p <0,001), PTX-3 (441.09 ± 295.64 vs. 279.99 ± 125.68 pg/ml, p < 0,001), Neopterin (9.97 ± 2.17 vs. 8.36 ± 2.68 nmol/l, p < 0,05) and IL-6 (32.5 ± 13.90 vs. 0.97 ± 0.77 pg/ml, p < 0,001) were significantly higher at S2 compared to S1. Conclusions: Running a marathon causes an acute rise in concentrations of inflammatory biomarkers. Further research is needed on the long-term effects of intensive endurance exercise on the cardiovascular system.

Keywords

EN

neopterin; endothelin-1; pentraxin-3; marathon; amateur runners

• Publisher: Gdański Uniwersytet Medyczny
• Journal: European Journal of Translational and Clinical Medicine
• Year: 2021
• Volume: 4
• Issue: 1
• Pages: 43-49

Dates

published

26 - 5 - 2021

Contributors

author

Anna Maria Kaleta-Duss

• Institute of Radiology, Cantonal Hospital of Aargau, Aarau, Switzerland

• https://orcid.org/0000000275029698

author

Zuzanna Lewicka-Potocka

• Department of Cardiology and Electrotherapy, Medical University of Gdańsk
• First Department of Cardiology, Medical University of Gdańsk, Poland

• https://orcid.org/0000000277161190

author

Alicja Dąbrowska-Kugacka

• Department of Cardiology and Electrotherapy, Medical University of Gdańsk

• https://orcid.org/0000000255467818

author

Grzegorz Raczak

• Department of Cardiology and Electrotherapy, Medical University of Gdańsk

• https://orcid.org/0000000185358658

author

Anna Siekierzycka

• Department of Medical Laboratory Diagnostics - Biobank BBMRI.pl, Medical University of Gdańsk, Poland

• https://orcid.org/0000000307572071

author

Marcin Woźniak

• Department of Medical Laboratory Diagnostics - Biobank BBMRI.pl, Medical University of Gdańsk, Poland
• Beckman Institute for Advanced Science and Technology, USA

• https://orcid.org/0000000172701592

author

Leszek Kalinowski

• Department of Medical Laboratory Diagnostics - Biobank BBMRI.pl, Medical University of Gdańsk, Poland

• https://orcid.org/0000000172701592

author

Ewa Katarzyna Lewicka

• Department of Cardiology and Electrotherapy, Medical University of Gdańsk

• https://orcid.org/0000000300802460

Identifiers

DOI

10.31373/ejtcm/136659

Biblioteka Nauki

1197575