Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results

Journal

2023 | 10 | 3 | 201-204

Article title

Troxerutin in the treatment of eye diseases - a proven substance rediscovered

Content

Title variants

Languages of publication

Abstracts

EN
Troxerutin is a well and for a long time known substance, it is a semi-synthetic bioflavonoid derived from rutin. Original substance is supplied from flowers of Styphnolobium japonicum tree.

The author discusses actual medical effects of troxerutin, including antioxidant, anti-inflammatory, antithrombosis and protecting endothelium of small vessels.

Being water-soluble, it can be used as ophthalmic drops in treatment of subconjunctival haemorrhage, vitreous haemorrhage and early stages of diabetic retinopathy.

Publisher

Journal

Year

Volume

10

Issue

3

Pages

201-204

Physical description

Dates

published
2023

Contributors

  • Specialist Ophthalmological Office “Eretina” in Poznan

References

  • Charakterystyka produktu leczniczego - trokserutyna. 2013.
  • He H, Bai Y, Zhao Z et al. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L. J Ethnopharmacol. 2016; 187: 160-82.
  • Zamanian M, Bezmandegan G, Sureda A et al. The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review. Curr Neuropharmacol. 2021; 19: 97-110.
  • Fahmideh F, Marchesi N, Campagnoli LIM et al. Effect of troxerutin in counteracting hyperglycemia-induced VEGF upregulation in endothelial cells: a new option to target early stages of diabetic retinopathy? Front Pharmacol. 2022; 13: 951833.
  • Ahmadi Z. Mohammadinejad R, Roomiani S et al. Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View. J Pharmacopuncture. 2021; 24: 1-13.
  • Qadiri A, Bavil FM, Hamidian GR et al. Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. Avicenna J Phytomed. 2019; 9: 374-85.
  • Aziz Z, Tang WL, Chong NJ et al. A systematic reviev of the efficacy and tolerability of hydroxyethylorutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015; 40: 177-85.
  • Nonikashvili Z, Jūratė Gerbutavičienė R. Ginkgo biloba, troxerutin and heptaminol chlorhydrate combined treatment for the management of venous insufficiency and hemorrhoidal crises. Eur Rev Med Pharmacol Sci. 2022; 26: 5200-9.
  • Tash NG, Cimen FK, Karakurt Y et al. Protective effects of Rutin against methanol induced acute toxic neuropathy: an experimental study. Int J Ophthalmol. 2018; 11: 780-5.
  • Celik A, Ersoy OF, Ozkan N et al. Comparison of effects of troxerutin and heparinoid on flap necrosis. J Plast Reconstr Aesthet Surg. 2010; 63: 875-83.
  • Glacet-Bernard A, Coscas G, Chabanel A et al. A Randomized, Double-Masked study of the Treatment of Retinal Vein Occlusin With Troxerutin. AJO. 1994; 118: 421-9.
  • Kaul A, Short WD, Wang X et al. Hyaluronidases in Human Diseases. Int J Mol Sci. 2021; 22: 3204.
  • Wang C, Pang Y. Nano-based eye drop: Topical and noninvasive therapy for ocular diseases. Adv Drug Deliv Rev. 2023; 194: 114721.

Document Type

Publication order reference

Identifiers

Biblioteka Nauki
23202887

YADDA identifier

bwmeta1.element.ojs-doi-10_24292_01_OT_200923_1
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.