Novel Ru(III), Rh(III), Pd(II) and Pt(II) complexes with ligands incorporating azole and pyrimidine rings. I. Antiproliferative activity in vitro

• Authors: M.Z. Wisniewski , J. Wietrzyk , A. Opolski
• Languages of publication: EN

Abstracts

EN

A number of co-ordination compounds of Ru(III), Rh(III), Pd(II) and Pt(II) with ligands incorporating azole and pyrimidine rings has been synthesized. The in vitro cell proliferation-inhibitory activity of these compounds was examined against human cancer cell lines: A 549 (lung carcinoma), LS-180 (colon cancer) and MCF-7 (breast cancer), using SRB technique. Six out of 13 compounds studied revealed cytotoxic activity in vitro. Inhibitory dose 50% (ID50) was lower than 4 g/ml, which is an activity criterion accepted in conventional in vitro cytotoxic screening tests. Two compounds revealed weak cytotoxic activity with ID50 higher than 4 g/ml and five compounds were inactive.

Keywords

EN

AZOLE; CANCER; CELL LINE; CYTOTOXIC ACTIVITY; HUMAN; IN VITRO; PYRIMIDINE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 1
• Pages: 51-55

Contributors

author

M.Z. Wisniewski

author

J. Wietrzyk

author

A. Opolski

• Document Type: SHORT COMMUNICA
• Publication order reference: M. Z. Wisniewski, Institute of Chemistry, Pedagogical University, Checinska 5, 25-020 Kielce, Poland