Kinetics of organophosphorus pesticide inhibition of acetylcholinesterase (E.C.3.1.1.7) from the head of Tryporyza nivella (Fabr.) (Lepidoptera:Pyralidae)

• Authors: G. Pandey
• Languages of publication: EN

Abstracts

EN

Kinetic constans(Kd, k2 and ki values) for the inhibition of the Tryporyza nivella head acetylcholinesterase (ChE)by organophosphorus (Trichlorfon, Malaoxon and Diazoxon) pesticides were determined in vitro.These compounds showed a high affinity for AChE and the affinity constans (Kd).There was a little variation among the phosphorylation constans (K2), indicating a minor role for the phosphorylation step in the inhibition process.The significant variation of the molecular reaction (ki) of these compounds could be attributed to variation in the Kd rather than to the K2.Trichlorfon, having a higher ki value, was found to be less toxic than Malaoxan and Diazoxon.

Keywords

EN

ACETYLCHOLINESTERASE; KINETIC CONSTANS; ORGANOPHOSPHORUS PESTICIDE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1995
• Volume: 43
• Issue: 3-4
• Pages: 161-167

Contributors

author

G. Pandey

• Document Type: article
• Publication order reference: G.Pandey