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Defence-Aggression Reaction including its cardiovascular components may be inhibited during habituation or by stimulation in the restricted area of the prefrontal cortex. During the process of habituation components of the Defence-Aggression Reaction are inhibited on the level of nucleus paragigatocellularis lateralis of the ventral lateral medulla. The prefrontal cortex probably plays an important role in developing inhibition during habituation of the Defence-Aggression Reaction.