The effect of changes in extracellular pH on neuronal GABAA receptors

• Authors: E.D. Zarnowska , K. Mercik , M. Mandat , J.W. Mozrzymas
• Languages of publication: PL

Abstracts

EN

Local pH values of both intra- and extracellular liquids can be regulated by a number of mechanisms including membrane transport and metabolism. It is known that the changes of extracellular pH accompanying physiological and pathological processes are sufficient to affect several important structures such as ionic channels, transporters, receptors etc. In particular, several reports indicate that GABAA receptor is strongly modulated by this factor. The effect of pH application of ultrafast perfusion system allowed to explore the mechanisms of pH effect on GABAA receptors in neurons. It is concluded that changes in pH exert their effects by allosteric modulation of GABAA receptors.

Keywords

EN

EXTRACELLULAR PH; GABAA RECEPTOR

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 3
• Pages: 293-305

Contributors

author

E.D. Zarnowska

author

K. Mercik

author

M. Mandat

author

J.W. Mozrzymas

• Document Type: ARTICLE
• Publication order reference: E.D. Zarnowska, Katedra i Zaklad Biofizyki AM, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland